Difference between revisions of "Dabigatran reversal"

Line 1: Line 1:
 
==Background==
 
==Background==
 +
*If aPTT is totally normal (<1.5x), unlikely that significant drug effect is present
  
 
==Reversal Protocol==
 
==Reversal Protocol==
 +
#Mild Bleeding
 +
##Local control measures
 +
##Delay next 1-2 dose OR discontinue as appropriate
 +
#Moderate-Severe Bleeding
 +
##Local control measures/surgical intervention
 +
##Symptomatic treatment
 +
##Fluids/blood/monitoring
 +
##Oral charcoal administration (if taken <2hrs before)
 +
##Hemodialysis (removes 60% over 2-3hrs)
 +
#Life-Threatening Bleeding
 +
##All above
 +
##Consider
 +
###rFVIIa
 +
###PCC
  
 
==Source==
 
==Source==
 +
Hennipin County Guidelines
 +
University of Utah Healthcare Thrombosis Service Guidelines
  
[[Category:Heme/Onch]]
+
[[Category:Heme/Onc]]
 
[[Category:Drugs]]
 
[[Category:Drugs]]

Revision as of 18:15, 9 June 2012

Background

  • If aPTT is totally normal (<1.5x), unlikely that significant drug effect is present

Reversal Protocol

  1. Mild Bleeding
    1. Local control measures
    2. Delay next 1-2 dose OR discontinue as appropriate
  2. Moderate-Severe Bleeding
    1. Local control measures/surgical intervention
    2. Symptomatic treatment
    3. Fluids/blood/monitoring
    4. Oral charcoal administration (if taken <2hrs before)
    5. Hemodialysis (removes 60% over 2-3hrs)
  3. Life-Threatening Bleeding
    1. All above
    2. Consider
      1. rFVIIa
      2. PCC

Source

Hennipin County Guidelines University of Utah Healthcare Thrombosis Service Guidelines