Difference between revisions of "Deferoxamine"

(Text replacement - " pt " to " patient ")
(Updated links and information for pharmacology/side effects)
 
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==General==
 
==General==
*Type:  
+
*Type: [[Antidote]]
 
*Dosage Forms:
 
*Dosage Forms:
*Routes of Administration:
+
*Routes of Administration: IV, IM
*Common Trade Names:  
+
*Common Trade Names: Desferal
  
 
==Adult Dosing==
 
==Adult Dosing==
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==Pediatric Dosing==
 
==Pediatric Dosing==
 +
===[[Iron toxicity]]===
 +
*15 mg/kg/h IV
 +
*Prolonged use >24-48 hours may increase risk of ARDS
 +
*100mg deferoxamine chelates 9mg free iron
  
 
==Special Populations==
 
==Special Populations==
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*[[Lactation risk categories|Lactation risk]]:
 
*[[Lactation risk categories|Lactation risk]]:
 
*Renal Dosing
 
*Renal Dosing
**Adult
+
**Adult: Contraindicated in severe impairment or anuria.
**Pediatric
+
**Pediatric: Contraindicated in severe impairment or anuria
 
*Hepatic Dosing
 
*Hepatic Dosing
**Adult
+
**Adult: Not defined
**Pediatric
+
**Pediatric: Not defined
  
 
==Indications==
 
==Indications==
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deferoxamine therapy. Dig Dis Sci 1991; 36:1154-1160.</ref>
 
deferoxamine therapy. Dig Dis Sci 1991; 36:1154-1160.</ref>
 
*Can see "vin rose" colored urine from chelated iron extretion
 
*Can see "vin rose" colored urine from chelated iron extretion
 +
*[[Cataracts]] with long term use
 +
*[[Angioedema]]
 +
*Flushing, urticaria, fever, myalgia, nausea, vomiting
  
 
==Pharmacology==
 
==Pharmacology==
*Half-life:  
+
*Half-life: 6h
*Metabolism:  
+
*Metabolism: Plasma
*Excretion:  
+
*Excretion: Urine, bile/feces
 
*Mechanism of Action:
 
*Mechanism of Action:
  
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==See Also==
 
==See Also==
 +
*[[Iron toxicity]]
  
 
==References==
 
==References==
 
<references/>
 
<references/>
 
[[Category:Pharmacology]]
 
[[Category:Pharmacology]]

Latest revision as of 21:50, 8 September 2018

General

  • Type: Antidote
  • Dosage Forms:
  • Routes of Administration: IV, IM
  • Common Trade Names: Desferal

Adult Dosing

Iron toxicity

  • 1000mg IV; start at 5mg/kg/hr, increase up to 15mg/kg/hr as tolerated for up to 24hrs
  • Subsequent doses are 500mg increments guided by clinical status of patient / urine color
  • Recommended amount during first 24hr is 360mg/kg not to exceed 6g.

Pediatric Dosing

Iron toxicity

  • 15 mg/kg/h IV
  • Prolonged use >24-48 hours may increase risk of ARDS
  • 100mg deferoxamine chelates 9mg free iron

Special Populations

  • Pregnancy Rating:
  • Lactation risk:
  • Renal Dosing
    • Adult: Contraindicated in severe impairment or anuria.
    • Pediatric: Contraindicated in severe impairment or anuria
  • Hepatic Dosing
    • Adult: Not defined
    • Pediatric: Not defined

Indications

  • Systemic toxicity and iron level > 350 mcg/dL
  • Metabolic acidosis
  • Progressive symptoms
  • Serum iron level >500 mcg/dL

Contraindications

  • Allergy to class/drug
  • Renal failure patients not on hemodialysis

Adverse Reactions

Pharmacology

  • Half-life: 6h
  • Metabolism: Plasma
  • Excretion: Urine, bile/feces
  • Mechanism of Action:

Comments

  • Chelates iron and creates a water-soluble compound ferrioxamine that is renally excreted and can be dialyzed.[2]

See Also

References

  1. Mazzoleni G. et al. Yersinia enterocolitica infection with ileal perforation associated with iron overload and deferoxamine therapy. Dig Dis Sci 1991; 36:1154-1160.
  2. Cite error: Invalid <ref> tag; no text was provided for refs named ironoverview