Desonide

Administration

  • Type: Corticosteroids
  • Dosage Forms: ointment 0.05%, cream 0.05%, lotion 0.05%
  • Routes of Administration: topical
  • Common Trade Names: Tridesilon, Verdeso, and Desonate

Adult Dosing

  • Apply 2-3 times per day to affected area
    • Do not use occlusive dressing
    • Avoid prolonged use on face, axilla, groin
    • Ointment is medium/low potency; Cream and lotion are low potency

Pediatric Dosing

  • Age 3 months and older: apply 2 times per day to affected area
    • Max use 4 weeks
    • Avoid prolonged use on face, axilla, groin
    • Ointment is medium/low potency; Cream and lotion are low potency

Special Populations

  • Pregnancy Rating: Category C
  • Lactation risk: May use short-term while breastfeeding but caution advised. Use lowest potency for nipple area and remove before breastfeeding.

Renal Dosing

  • Adult: N/A
  • Pediatric: N/A

Hepatic Dosing

  • Adult: N/A
  • Pediatric: N/A

Contraindications

  • Allergy to class/drug

Caution

  • Pediatric patients
  • Superimposed skin infection

Adverse Reactions

Serious

  • Central serous chorioretinopathy
  • HPA axis suppression (prolonged use)
  • Cushing syndrome (prolonged use)
  • Hyperglycemia (prolonged use)
  • Cataracts (prolonged use)
  • Glaucoma (prolonged use)
  • Intracranial hypertension (prolonged use in peds)

Common

  • URI
  • Cough
  • Burning
  • Stinging
  • Headache
  • Skin atrophy
  • Irritation
  • Dryness
  • Pruritis
  • Folliculitis
  • Acneiform dermatitis
  • Hypopigmentation
  • Perioral dermatitis
  • Allergic contact dermatitis
  • Secondary infection
  • Straie
  • Milaria

Pharmacology

  • Half-life: Unknown
  • Metabolism: Liver;CYP450
  • Excretion: Urine

Mechanism of Action

  • Exact mechanism unknown; anti-inflammatory
    • Inhibits multiple inflammatory cytokines
    • Produces glucocorticoid and mineralocorticoid effects

Comments

See Also

References

  • Epocrates