Disseminated intravascular coagulation

Revision as of 09:33, 12 October 2011 by Jswartz (talk | contribs)

Background

  1. Distinguishing the coagulopathy of severe liver disease from DIC is difficult
Abnormal laboratory values, including decreased platelets, decreased coagulation factors, and hypofibrinogenemia can be present in both conditions. However, the D-dimer assay should be normal or only minimally elevated from liver disease alone.


Causes

  1. infection
  2. carcinoma
  3. acute leukemia
  4. trauma (head)
  5. shock
  6. liver disease
  7. pregnancy
  8. vascular disease
  9. envenomation
  10. ARDS
  11. transfusion reaction

Diagnosis

  1. PT high
  2. PTT high
  3. Platlet low
  4. Fibrinogen low
  5. FDP high
  6. D-dimer high
  7. RBCs fragmented


Treatment

See Heme: Bleeding Treatment

Source

1/26/06 DONALDSON (addapted from Tintinalli)