Difference between revisions of "Dobutamine"

(General)
 
(15 intermediate revisions by 7 users not shown)
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==Adult Dosing==
 
==Adult Dosing==
 +
===Dosing===
 +
*2-20mcg/kg/min
 +
**10mcg works for most
 +
*May use in peripheral IV
 +
===Rate of Titration===
 +
*Q2-5 min
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
Line 11: Line 17:
 
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
 
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
 
*Lactation:
 
*Lactation:
 +
** Unknown if Dobutamine passes into breast milk
 
*Renal Dosing
 
*Renal Dosing
 
**Adult
 
**Adult
 +
*** Not defined
 
**Pediatric
 
**Pediatric
 +
*** Not defined
 
*Hepatic Dosing
 
*Hepatic Dosing
 
**Adult
 
**Adult
 +
*** Not defined
 
**Pediatric
 
**Pediatric
 +
*** Not defined
  
 
==Contraindications==
 
==Contraindications==
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==Adverse Reactions==
 
==Adverse Reactions==
 +
*Tachyarrhythmias
 +
*Myocardial ischemia
 +
*[[Hypotension]] as β<sub>2</sub> effect may result in vasodilation
 +
**Caution if SBP <90
 +
 
===Serious===
 
===Serious===
  
 
===Common===
 
===Common===
  
==Pharmacology==
+
==Pharmacology,ref>Dobutamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>==
 
*Half-life:  
 
*Half-life:  
 +
** 2 minutes
 
*Metabolism:  
 
*Metabolism:  
 +
** In tissues and hepatically
 
*Excretion:  
 
*Excretion:  
*Mechanism of Action:
+
** Urine as metabolites
 +
*Mechanism of Action:β<sub>1</sub> stimulation with variable BP effects
 +
===Primary Receptor===
 +
*β<sub>1</sub>
 +
*β<sub>2</sub>
 +
===Relative Effects===
 +
*↑↑↑SV
 +
*↑↑HR → increases oxygen demand of heart → can worsen ischemia
 +
*↓SVR (transient, from β<sub>2</sub> agonism)
 +
 
 +
==Notes==
 +
===Indications===
 +
*Cardiogenic shock
 +
**initial agent in low-output heart failure without requiring BP support
 +
*Tricyclic overdose
 +
*septic shock with low cardiac output to improve blood flow
  
 
==See Also==
 
==See Also==
 +
http://www.atsjournals.org/doi/abs/10.1164/rccm.201006-0972CI?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#readcube-epdf
  
==Sources==
+
==References==
 +
<references/>
  
<references/>
+
[[Category:Pharmacology]]
[[Category:Drugs]]
 

Latest revision as of 04:21, 2 May 2019

General

Adult Dosing

Dosing

  • 2-20mcg/kg/min
    • 10mcg works for most
  • May use in peripheral IV

Rate of Titration

  • Q2-5 min

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
    • Unknown if Dobutamine passes into breast milk
  • Renal Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined
  • Hepatic Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Tachyarrhythmias
  • Myocardial ischemia
  • Hypotension as β2 effect may result in vasodilation
    • Caution if SBP <90

Serious

Common

Pharmacology,ref>Dobutamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>

  • Half-life:
    • 2 minutes
  • Metabolism:
    • In tissues and hepatically
  • Excretion:
    • Urine as metabolites
  • Mechanism of Action:β1 stimulation with variable BP effects

Primary Receptor

  • β1
  • β2

Relative Effects

  • ↑↑↑SV
  • ↑↑HR → increases oxygen demand of heart → can worsen ischemia
  • ↓SVR (transient, from β2 agonism)

Notes

Indications

  • Cardiogenic shock
    • initial agent in low-output heart failure without requiring BP support
  • Tricyclic overdose
  • septic shock with low cardiac output to improve blood flow

See Also

http://www.atsjournals.org/doi/abs/10.1164/rccm.201006-0972CI?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#readcube-epdf

References