Dobutamine: Difference between revisions
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===Common=== | ===Common=== | ||
==Pharmacology== | ==Pharmacology,ref>Dobutamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>== | ||
*Half-life: | *Half-life: | ||
** 2 minutes | ** 2 minutes | ||
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==References== | ==References== | ||
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[[Category:Pharmacology]] | [[Category:Pharmacology]] |
Revision as of 04:21, 2 May 2019
General
- Type: Vasopressors
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Dosing
- 2-20mcg/kg/min
- 10mcg works for most
- May use in peripheral IV
Rate of Titration
- Q2-5 min
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Unknown if Dobutamine passes into breast milk
- Renal Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
- Hepatic Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
Contraindications
- Allergy to class/drug
Adverse Reactions
- Tachyarrhythmias
- Myocardial ischemia
- Hypotension as β2 effect may result in vasodilation
- Caution if SBP <90
Serious
Common
Pharmacology,ref>Dobutamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>
- Half-life:
- 2 minutes
- Metabolism:
- In tissues and hepatically
- Excretion:
- Urine as metabolites
- Mechanism of Action:β1 stimulation with variable BP effects
Primary Receptor
- β1
- β2
Relative Effects
- ↑↑↑SV
- ↑↑HR → increases oxygen demand of heart → can worsen ischemia
- ↓SVR (transient, from β2 agonism)
Notes
Indications
- Cardiogenic shock
- initial agent in low-output heart failure without requiring BP support
- Tricyclic overdose
- septic shock with low cardiac output to improve blood flow