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General
- Type: Vasopressors
- Dosage Forms: IV
- Common Trade Names: Intropin
Indications
- Hypotension caused by:
- Septic shock
- Bradycardia
- MI
- Trauma/spinal shock
- Heart failure
Adult Dosing
- Shock (adjunct):
- 1-50 mcg/kg/min IV
- Max 20-50 mcg/kg/min
- Increase 1-4 mcg/kg/min q10-30 min, titrate to effect
- Refractory Heart Failure:
- Bradycardia (in patients unresponsive to atropine):
- Post-resuscitation stabilization:
Pediatric Dosing
- Shock (adjunct):
- 5-10 mcg/kg/min IV (max dose of 20 mcg/kg/min)
- Increase 1-4 mcg/kg/min q10-30 min, titrate to effect
- Post-resuscitation stabilization:
Special Populations
- Pregnancy Rating: Class C
- Lactation: Use caution (limited data)
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: N/A
- Pediatric: N/A
Contraindications
- Allergy to class/drug
- Tachyarrhythmias
- Pheochromocytoma
Adverse Reactions
Serious
Common
Pharmacology[1]
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Primary Receptor
- Low dose: DA, β1
- High dose: DA, α1 >> β1
Relative Effects
- Low dose: Natriuresis, ↑↑HR, ↑↑SV
- High dose: ↑SVR and ↑SV
See Also
References
- ↑ Dopamine: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.