EBQ:Mortality in Multicenter Critical Care Trials: An Analysis of Interventions with a Significant Effect: Difference between revisions

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Of all the interventions done in critical care, the authors of this study identified ''15 total treatments that increased or decreased mortality as documented in a randomized, controlled trail''.  
Of all the interventions done in critical care, the authors of this study identified ''15 total treatments that increased or decreased mortality as documented in a randomized, controlled trail''.  


The following are interventions that decreased mortality:
'''The following interventions decreased mortality''':
# Noninvasive Ventilation
# Noninvasive Ventilation
# Mild hypothermia after cardiac arrest
# Mild hypothermia after cardiac arrest
# Prone Positioning
# Low tidal volume ventilation in ARDS
# TXA in patients with or at high risk of traumatic hemorrhagic shock
# Daily interruption of sedatives in critically ill patients
# Albumin in cirrhotic patients with SBP
 
'''The following interventions increased mortality''':
# Diaspirin cross linked hemoglobin in traumatic hemorrhagic shock
# Starch in septic shock
# Ventilation with high frequency oscillation
# IV Salbutamol in ARDS
# Glutamine supplementation
# Growth hormone treatment
# Supernormal systemic oxygen delivery
# Intensive insulin therapy


==Major Points==  
==Major Points==  

Revision as of 00:14, 12 January 2016

Incomplete Journal Club Article
Landoni G et al. "Mortality in Multicenter Critical Care Trials: An Analysis of Interventions With a Significant Effect". Critical Care Medicine. 2015. 43(8):1559–1568.
PubMed Full text PDF

Clinical Question

What interventions have been shown in multicenter RCT's to affect mortality in adult critically ill patients?

Conclusion

Of all the interventions done in critical care, the authors of this study identified 15 total treatments that increased or decreased mortality as documented in a randomized, controlled trail.

The following interventions decreased mortality:

  1. Noninvasive Ventilation
  2. Mild hypothermia after cardiac arrest
  3. Prone Positioning
  4. Low tidal volume ventilation in ARDS
  5. TXA in patients with or at high risk of traumatic hemorrhagic shock
  6. Daily interruption of sedatives in critically ill patients
  7. Albumin in cirrhotic patients with SBP

The following interventions increased mortality:

  1. Diaspirin cross linked hemoglobin in traumatic hemorrhagic shock
  2. Starch in septic shock
  3. Ventilation with high frequency oscillation
  4. IV Salbutamol in ARDS
  5. Glutamine supplementation
  6. Growth hormone treatment
  7. Supernormal systemic oxygen delivery
  8. Intensive insulin therapy

Major Points

Study Design

Population

Patient Demographics

Inclusion Criteria

Exclusion Criteria

Interventions

Outcomes

Primary Outcome

Secondary Outcomes

Subgroup analysis

Criticisms & Further Discussion

External Links

See Also

Funding

References

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