EBQ:ProMISe Trial: Difference between revisions

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Revision as of 16:59, 8 May 2015

incomplete Journal Club Article
Mouncey PR, Osborn TM, Power GS, et al. "Trial of Early, Goal-Directed Resuscitation for Septic Shock". NEJM. 2015. 14(372):1301-1311.
PubMed Full text

Clinical Question

Is there a different between EGDT versus “usual care” in 90-day mortality?


Using EGDT did not lead to an improved outcome

Major Points

Study Design


56 hospitals in the UK

Patient Demographics

Inclusion Criteria

  • ≥18 years of age
  • Within 6 hours of presenting to ED
  • Known or presumed infection
  • 2 or more SIRS criteria
  • Refractory hypotension (<90 SBP or <65 MAP after 1L IVF trial) or hyperlactatemia (≥4.0)

Exclusion Criteria

  • CVA
  • ACS
  • Cardiac dysrhythmia
  • Acute pulmonary edema
  • GI bleed
  • Seizure
  • Drug overdose
  • Burn or trauma
  • Immediate surgery needed
  • CD4 count <50
  • Advance directive that restricts either protocol
  • Contraindication to interventions including refusal of blood transfusions
  • Pregnant
  • Transfer patient


  • Radomization within 2 hours after meeting criteria

Group 1 – EGDT (n=623)

  • Airway/breathing
  • Central line with oximetric port
  • Sedation, analgesia, and/or paralysis
  • IVF per CVP
  • Vasoactive agents per MAPs
  • Transfusion and inotrope agents per ScvO2
  • Reassess

Group 2 – Usual Care (n=620)

  • Airway/Breathing
  • 2 large bore IVs (or central line if not achieved)
  • Sedation, analgesia, and/or paralysis
  • Resuscitate with 2L IVF
  • IVF and vasopressors per MAPs
  • Reassess


Primary Outcome

Secondary Outcomes

Subgroup analysis

Criticisms & Further Discussion

External Links