Difference between revisions of "Enoxaparin"

(Text replacement - "Cr " to "creatinine ")
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==General==
 
==General==
 
*Type: [[Low molecular weight heparin]]
 
*Type: [[Low molecular weight heparin]]
*Dosage Forms:
+
*Dosage Forms: subcutaneous
 
*Common Trade Names: Lovenox
 
*Common Trade Names: Lovenox
  
 
==Adult Dosing==
 
==Adult Dosing==
 +
*[[DVT]] ''prophylaxis'': 40mg SC daily
 +
*Therapeutic anticoagulation (e.g. treating DVT/PE, unstable angina): 1mg/kg SC q12h
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
 +
''Off-label''
 +
*DVT prophylaxis:
 +
**<2 months: 0.75 mg/kg SC q12hr 
 +
**≥2 months: 0.5 mg/kg SC q12h
 +
*Therapeutic anticoagulation:
 +
**<2 months: 1.5 mg/kg SC q12hr
 +
**≥2 months: 1 mg/kg SC q12hr
  
 
==Special Populations==
 
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
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*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*Lactation:
+
*Lactation: Unknown risk
 
*Renal Dosing
 
*Renal Dosing
 
**Renal impairment (creatinine clearance <30)
 
**Renal impairment (creatinine clearance <30)
 
***Use 50% of usual dose or use UFH instead
 
***Use 50% of usual dose or use UFH instead
**Adult
+
*Hepatic Dosing: not established
**Pediatric
 
*Hepatic Dosing
 
**Adult
 
**Pediatric
 
 
*Obesity
 
*Obesity
 
**Weight-based dosing safe up to 190kg (no data available thereafter)
 
**Weight-based dosing safe up to 190kg (no data available thereafter)
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==Pharmacology==
 
==Pharmacology==
*Half-life:  
+
*Half-life: 4.5h
*Metabolism:  
+
*Metabolism: hepatic
*Excretion:  
+
*Excretion: urine
*Mechanism of Action:
+
*Mechanism of Action: inhibits factor Xa by increasing inhibition rate of clotting proteases that are activated by antithrombin III
  
 
==See Also==
 
==See Also==

Revision as of 19:19, 22 September 2019

General

Adult Dosing

  • DVT prophylaxis: 40mg SC daily
  • Therapeutic anticoagulation (e.g. treating DVT/PE, unstable angina): 1mg/kg SC q12h

Pediatric Dosing

Off-label

  • DVT prophylaxis:
    • <2 months: 0.75 mg/kg SC q12hr
    • ≥2 months: 0.5 mg/kg SC q12h
  • Therapeutic anticoagulation:
    • <2 months: 1.5 mg/kg SC q12hr
    • ≥2 months: 1 mg/kg SC q12hr

Special Populations

  • Pregnancy Rating: B
  • Lactation: Unknown risk
  • Renal Dosing
    • Renal impairment (creatinine clearance <30)
      • Use 50% of usual dose or use UFH instead
  • Hepatic Dosing: not established
  • Obesity
    • Weight-based dosing safe up to 190kg (no data available thereafter)

Indications

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Bleeding
  • Pruritus
  • Local skin reaction

Pharmacology

  • Half-life: 4.5h
  • Metabolism: hepatic
  • Excretion: urine
  • Mechanism of Action: inhibits factor Xa by increasing inhibition rate of clotting proteases that are activated by antithrombin III

See Also

References