Difference between revisions of "Enoxaparin"

(Text replacement - "Category:Drugs" to "Category:Pharmacology")
(Adverse Reactions)
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==Adverse Reactions==
 
==Adverse Reactions==
#Bleeding
+
*Bleeding
##Less common than with UFH
+
**Treatment = Protamine
##Treatment
+
***Does not completely reverse LMWHs
###Protamine
+
***Carries significant anaphylaxis risk (0.2%); only use for major bleeding
####Does not completely reverse LMWHs
+
***Protamine 1mg IV for every 1mg of enoxaparin given in previous 8h
####Carries significant anaphylaxis risk (0.2%); only use for major bleeding
+
****If 8–12h since last enoxaparin dose give 0.5mg IV for every 1mg of enoxaparin given
####Dosing
+
*Pruritus
#####For Enoxaparin: protamine 1mg IV for every 1mg of enoxaparin given in previous 8h
+
*Local skin reaction
######If 8–12h since last enoxaparin dose give 0.5mg IV for every 1mg of enoxaparin given
 
#Pruritus
 
#Local skin reaction
 
  
 
==Pharmacology==
 
==Pharmacology==

Revision as of 13:34, 3 April 2016

General

Adult Dosing

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Renal impairment (Cr clearance <30)
      • Use 50% of usual dose or use UFH instead
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric
  • Obesity
    • Weight-based dosing safe up to 190kg (no data available thereafter)

Indications

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Bleeding
    • Treatment = Protamine
      • Does not completely reverse LMWHs
      • Carries significant anaphylaxis risk (0.2%); only use for major bleeding
      • Protamine 1mg IV for every 1mg of enoxaparin given in previous 8h
        • If 8–12h since last enoxaparin dose give 0.5mg IV for every 1mg of enoxaparin given
  • Pruritus
  • Local skin reaction

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Sources