Enoxaparin

Revision as of 13:34, 3 April 2016 by Rossdonaldson1 (talk | contribs) (Adverse Reactions)

General

Adult Dosing

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Renal impairment (Cr clearance <30)
      • Use 50% of usual dose or use UFH instead
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric
  • Obesity
    • Weight-based dosing safe up to 190kg (no data available thereafter)

Indications

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Bleeding
    • Treatment = Protamine
      • Does not completely reverse LMWHs
      • Carries significant anaphylaxis risk (0.2%); only use for major bleeding
      • Protamine 1mg IV for every 1mg of enoxaparin given in previous 8h
        • If 8–12h since last enoxaparin dose give 0.5mg IV for every 1mg of enoxaparin given
  • Pruritus
  • Local skin reaction

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Sources