Eosinophilic granulomatosis with polyangiitis

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  • Formerly known as Churg-Strauss Syndrome
  • Chronic sinusitis, asthma, and peripheral eosinophilia
  • Vasculitis of small and medium sized vessels
  • Lung and skin are most commonly involved

Vasculitis Syndrome Types

Clinical Features

Classically develops in three sequential phases:

  1. Prodrome
  2. Eosinophilic phase
    • Multiorgan involvement, particularly lung and GI tract
    • Caused by eosinophilic infiltration into these organs
  3. Vasculitic phase
    • Life threatening vasculitis associated with vascular and extravascular granulomatosis
    • May present with nonspecific signs such as fever, weight loss, malaise

Differential Diagnosis


  • Typically a clinical diagnosis
  • Labs with elevated eosinophils, ESR, CRP, ANCA
  • CXR with transient, patchy opacities


Acute Therapy

Maintenance Therapy


  • Refer to rheumatology

See Also

External Links