Famciclovir: Difference between revisions
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | ||
*Lactation: | *Lactation: Safety Unknown | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult | ||
Revision as of 21:13, 29 June 2015
General
- Type: DNA polymerase inhibitor
- Dosage Forms: 125, 250, 500 PO
- Common Trade Names: Famvir
Adult Dosing
HSV-1
- 500mg PO TID
Pediatric Dosing
Special Populations
- Pregnancy Rating: B
- Lactation: Safety Unknown
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- caution if renal impairment
Adverse Reactions
Serious
- neutropenia
- thrombocytopenia
- skin rxn, severe
- hallucinations
- delirium
Common
- headache
- nausea
- diarrhea
- vomiting
- fatigue
- pruritus
- neutropenia
- abnormal LFTs
- paresthesia
- flatulence
Pharmacology
- Half-life: 2-3h
- Metabolism: liver, CYP450
- Excretion: urine primarily, feces
- Mechanism of Action: inhibits DNA polymerase, selectively inhibiting herpes viral DNA synthesis and replication