Famciclovir

General

  • Type: DNA polymerase inhibitor
  • Dosage Forms: 125, 250, 500 PO
  • Common Trade Names: Famvir

Adult Dosing

HSV-1

  • 500mg PO TID

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • neutropenia
  • thrombocytopenia
  • skin rxn, severe
  • hallucinations
  • delirium

Common

Pharmacology

  • Half-life: 2-3h
  • Metabolism: liver, CYP450
  • Excretion: urine primarily, feces
  • Mechanism of Action: inhibits DNA polymerase, selectively inhibiting herpes viral DNA synthesis and replication

See Also

Sources

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