Flurazepam

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Administration

  • Type: Benzodiazepine
  • Dosage Forms: CAP 15mg, 30mg
  • Routes of Administration: Oral
  • Common Trade Names: Dalmane

Adult Dosing

Insomnia, short term tx

  • 15mg PO qhs

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

Pregnancy Rating

  • Category C
  • Consider alternatives in pregnancy
  • Risk of neonatal withdrawal and floppy infant syndrome

Lactation risk

  • Use alternative or consider short-acting benzodiazepines while breastfeeding

Renal Dosing

  • Adult: No adjustment
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined.
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug
  • Pregnancy
  • Avoid abrupt withdrawal with long-term use

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 2-3h; 40-100h active metabolite
  • Metabolism: Liver extensively; 3A4 partial substrate
  • Excretion: Urine

Mechanism of Action

Comments

See Also

References