Glipizide

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Administration

  • Type: Sulfonylurea
  • Dosage Forms:
  • Routes of Administration:
  • Common Trade Names: Glucotrol

Adult Dosing

  • 5-10mg PO daily

Pediatric Dosing

Safety/efficacy not established

Special Populations

Pregnancy Rating

  • Category C

Lactation risk

  • Excretion minimal, likely safe

Renal Dosing

  • Not studied

Hepatic Dosing

  • 2.5mg daily

Contraindications

  • Allergy to class/drug (including sulfa allergy)
  • Type 1 diabetes
  • Diabetic ketoacidosis
  • Caution if risk of severe hypoglycemia (elderly, debilitated, malnourished, adrenal/pituitary insufficiency, physiologic stressors)
  • Concomitant use of beta blockers or other sympatholytics (may impair ability to recognize symptoms of hypoglycemia)

Adverse Reactions

Serious

Common

  • Hypoglycemia
  • Rash, skin eruptions
  • Abdominal pain, diarrhea, constipation, flatulence, heartburn, nausea/vomiting
  • Syncope
  • Headache, dizziness, anxiety, depression, drowsiness

Pharmacology

  • Half-life: 2-5h
  • Metabolism: Hepatic
  • Excretion: Urinary

Mechanism of Action

  • Increases insulin secretion from pancreatic beta cells. May decrease rate of hepatic glucose production and increase insulin receptor sensitivity

Comments

See Also

References

Authors: