View source for Glycopyrrolate

==Administration==
*Class: [[Anticholinergics]]
*Routes of Administration: Oral, IV, IM
*Dosage Forms: 1-2 mg tablets, 1 mg/5mL oral solution, 0.2 mg/mL injectable solution
*Common Trade Names: Robinul, Cuvposa

==Adult Dosing==
*[[PUD]], adjunct tx
**PO Dose: 1-2 mg PO bid-tid;
***Start: 1 mg PO tid
***Max: 8 mg/day
**IM/IV Dose: 0.1-0.2 mg IM/IV tid-QID
***Max: 0.8 mg/day
***Space dose 4h apart
*Antisialagogue
**PO Dose: 1-2 mg PO bid-tid;
***Max: 8 mg/day
**Parenteral Dose: 0.1-0.2 mg SC/IM/IV q4-8h PRN
***Max: 0.8 mg/day

==Pediatric Dosing==
*Antisialagogue
**PO Dose, 2+ yo: 0.04-0.1 mg/kg PO q4-8h PRN
***Max: 1-2 mg/dose, 8mg/day
**Parenteral Dose, 2+ yo: 0.0004-0.01 mg/kg SC/IM/IV q4-8h PRN
***Max: 0.1-0.2 mg/dose, 0.8 mg/day

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: B; No known risk of teratogenicity with INJ form at 5x MRHD and with PO form at 320x MRHD
*Lactation risk: L3; Safety unknown

===Renal Dosing===
*Adult: Not defined; consider decreased dose.
*Pediatric: No defined; consider decreased dose.
===Hepatic Dosing===
*Adult: Not defined.
*Pediatric: Not defined.

==Contraindications==
*Allergy to class/drug
*Neonates (benzyl alcohol-containing INJ forms)
*[[Glaucoma]], angle-closure
*Obstructive uropathy
*GI Obstruction
*Paralytic ileus
*[[Toxic megacolon]]
*[[Ulcerative colitis]], severe
*Intestinal atony in elderly, debilitated pts
*[[Myasthenia gravis]]
*Acute hemorrhage with unstable cardiovascular status
*Caution if CAD
*Caution if [[HTN]]
*Caution if [[CHF]]
*Caution if [[arrhythmia]]
*Caution in elderly/debilitated pts
*Caution if renal impairment
*Caution if pulmonary disease
*Caution if [[hyperthyroidism]]
*Caution if autonomic neuropathy
*Caution if BPH
*Caution if high environmental temperature
*Caution if [[febrile]]
*Caution if [[ulcerative colitis]]
*Caution if hiatal hernia with reflux [[esophagitis]]

==Adverse Reactions==
===Serious===
*Hypersensitivity reaction
*[[Anaphylaxis]]
*Intestinal obstruction
*[[Heat stroke]]
*[[Seizure]]
*[[Arrhythmia]]
*[[Cardiac arrest]]
*[[Respiratory arrest]]

===Common===
*Xerostomia
*[[Vomiting]]
*[[Constipation]]
*Flushing
*[[Headache]]
*[[Urinary retention]]
*Urinary hesitancy
*Blurred vision
*Palpation
*[[Tachycardia]]
*Anhidrosis
*Dysgeusia
*Lactation suppression

==Pharmacology==
*Half-life: 0.83h
*Metabolism: Unknown
*Excretion: Urine 85%, bile

==Mechanism of Action==
*Antagonizes acetylcholine receptors.

==Comments==


==See Also==


==References==
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[[Category:Pharmacology]]