Griseofulvin

Administration

• Type: Antifungal
• Dosage Forms: Suspension 125mg/5ml; Tablet 125mg, 250mg, 500mg
• Routes of Administration: Oral
• Common Trade Names: Grifulvin V, Gris-PEG

Adult Dosing

• 250-1000mg PO daily

Pediatric Dosing

• 13.6-22.7kg: 125-250mg PO daily
• >22.7kg: 250-500mg PO daily

Special Populations

• Pregnancy Rating: X
• Lactation risk: Not recommended given potential for serious side effects.
• Renal dosing: none
• Hepatic dosing: none

Contraindications

• Allergy to class/drug
• Hepatocellular failure
• Porphyria
• Pregnancy

Adverse Reactions

Serious

• Acroparesthesia

Common

• Photosensitivity, rash, urticaria
• Nausea/vomiting, diarrhea
• Headache

Pharmacology

• Half-life: 9-22h
• Metabolism: Liver
• Excretion: Urine, feces, perspiration

Mechanism of Action

• Fungistatic, deposits into keratin precursor cells and inhibits fungal mitosis

See Also

• Antifungals
• Fungal infections
• Tinea