Gyromitra mushrooms: Difference between revisions
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[[File:Gyromitra_mushrooms.jpg|thumb|Gyromitra mushrooms]] | [[File:Gyromitra_mushrooms.jpg|thumb|Gyromitra mushrooms]] | ||
==Overview== | |||
*Also known as "brain fungi" | *Also known as "brain fungi" | ||
*Fruit in the spring and early summer | *Fruit in the spring and early summer | ||
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*Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite | *Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite | ||
==Clinical findings== | |||
*GI upset, fatigue, muscle cramps | *GI upset, fatigue, muscle cramps | ||
*Can present with refractory seizures due to GABA deficiency | *Can present with refractory seizures due to GABA deficiency | ||
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*Rarely methemoglobinemia | *Rarely methemoglobinemia | ||
==Treatment== | |||
*Supportive care | *Supportive care | ||
*High dose pyridoxine for refractory seizures (5g IV initially) | *High dose pyridoxine for refractory seizures (5g IV initially) | ||
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*Folinic acid supplementation (hydrazines inhibit MTHF production) | *Folinic acid supplementation (hydrazines inhibit MTHF production) | ||
=== | ==References== | ||
<references/> | |||
Revision as of 01:45, 11 January 2016
Overview
- Also known as "brain fungi"
- Fruit in the spring and early summer
- Frequently mistaken for morel mushrooms[1]
- Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite
Clinical findings
- GI upset, fatigue, muscle cramps
- Can present with refractory seizures due to GABA deficiency
- Hemolysis usually mild
- Rarely methemoglobinemia
Treatment
- Supportive care
- High dose pyridoxine for refractory seizures (5g IV initially)
- Avoid phenobarbital, especially in liver failure
- Methylene blue for severe methemoglobinemia
- Folinic acid supplementation (hydrazines inhibit MTHF production)
References
- ↑ Brozen R et al. Gyromitra Mushroom Toxicity. Apr 14, 2015. http://emedicine.medscape.com/article/817931-treatment#showall.