Hodgkin's lymphoma: Difference between revisions
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==Background== | ==Background== | ||
*Spreads from source lymph node to adjacent nodes | *Spreads from source lymph node to adjacent nodes | ||
*About half of cases related to [[Epstein-Barr virus]]<ref>World Cancer Report 2014. World Health Organization. 2014. pp. Chapter 2.4</ref> | |||
**[[HIV]] is also a risk factor | |||
*More common in males | |||
*Bimodal distribution: young adulthood and older aged | *Bimodal distribution: young adulthood and older aged | ||
*Most common malignancy | *Most common malignancy in ages 15-19 years | ||
*Survival | *Survival >90% in low-risk patients | ||
==Clinical Features== | ==Clinical Features== | ||
*Painless, firm, lymph node (usually cervical or supraclavicular) | *Painless, firm, [[lymphadenopathy|lymph node]] (usually cervical or supraclavicular) | ||
*"B" symptoms: fever, night sweats, | *"B" symptoms: [[fever]], night sweats, weight loss | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Cervical lymphadenopathy DDX}} | {{Cervical lymphadenopathy DDX}} | ||
{{Leuk/lymph DDX}} | {{Leuk/lymph DDX}} | ||
{{Lymphadenitis DDX}} | |||
==Evaluation== | ==Evaluation== | ||
*CXR | *[[CXR]] | ||
*CT neck/ | *CT neck/chest/abdomen/pelvis | ||
* | *Lymph node biopsy | ||
**Reed-Sternberg cells next to normal lymphocytes | |||
==Management== | ==Management== | ||
*Manage acute complications | *Manage acute complications | ||
**Superior vena cava syndrome | **[[Superior vena cava syndrome]] | ||
**Upper airway compression | **Upper airway compression | ||
***Do NOT give steroids | ***Do NOT give steroids (''citation/rationale?'') | ||
**[[Tumor lysis syndrome]] | |||
**[[Neutropenic fever]] | |||
**Chemo-induced [[nausea/vomiting]] | |||
==See Also== | ==See Also== | ||
*[[Lymphoma]] | *[[Lymphoma]] | ||
*[[Non-Hodgkin's lymphoma]] | |||
*[[Oncologic emergencies]] | *[[Oncologic emergencies]] | ||
==References== | ==References== | ||
<references/> | |||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Latest revision as of 21:44, 9 September 2020
Background
- Spreads from source lymph node to adjacent nodes
- About half of cases related to Epstein-Barr virus[1]
- HIV is also a risk factor
- More common in males
- Bimodal distribution: young adulthood and older aged
- Most common malignancy in ages 15-19 years
- Survival >90% in low-risk patients
Clinical Features
- Painless, firm, lymph node (usually cervical or supraclavicular)
- "B" symptoms: fever, night sweats, weight loss
Differential Diagnosis
Cervical Lymphadenopathy
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Mononucleosis
- Toxoplasmosis
- Branchial cleft lesions
- Cat scratch disease
- Mycobacterial adenitis
Acute Leukemia/Lymphoma
Lymphadenitis
Infectious
- Reactive adenitis
- Bacterial lymphadenitis
- Tuberculous lymphadenitis
- Cellulitis
- Cat-scratch disease
- Parotitis
- Lymphangitis
- Toxoplasmosis
- Tularemia
- Viral disease
- Fungal disease
- Reactive adenitis
Non-Infectious
- Malignancy
- Lymphoma
- Metastatic cancer
- Rheumatologic Disease
- Kawasaki Disease
- Systemic lupus erythematosus
- Sarcoidosis
- Juvenile Idiopathic Arthritis
- Langerhans Cell Histiocytosis
- Cutaneous Lesions:
- Bacillary angiomatosis
- Purpura
- Hematomas
- Angiomas
- Dermatofibromas
- Nevi
- Drug reaction
- Postvaccination
- Sarcoidosis
- Salivary gland diagnoses
Evaluation
- CXR
- CT neck/chest/abdomen/pelvis
- Lymph node biopsy
- Reed-Sternberg cells next to normal lymphocytes
Management
- Manage acute complications
- Superior vena cava syndrome
- Upper airway compression
- Do NOT give steroids (citation/rationale?)
- Tumor lysis syndrome
- Neutropenic fever
- Chemo-induced nausea/vomiting
See Also
References
- ↑ World Cancer Report 2014. World Health Organization. 2014. pp. Chapter 2.4