Hydrocortisone topical
General
- Type: Topical steroid
- Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint
- Common Trade Names: Cortizone, Cortaid, Hytone, Texacort
Adult Dosing
Dermatoses, steroid-responsive
- Apply bid-QID
Pediatric Dosing
Dermatoses, steroid-responsive
- Apply bid-QID
Special Populations
- Pregnancy Rating: C
- Lactation: Excretion in milk unknown; use with caution
- Renal Dosing: None
- Hepatic Dosing: None
Contraindications
- Allergy to class/drug
- caution if skin infection
- caution in pediatric patients
Adverse Reactions
Serious
- HPA axis suppresion
- Cushing syndrome
- hyperglycemia
- intracranial hypertension (pediatric patients)
Common
- burning
- pruritus
- irritation
- dryness
- folliculitis
- hypertrichosis
- acneiform dermatitis
- hypopigmentation
- perioral dermatitis
- allergic contact dermatitis
- maceration
- secondary infection
- skin atrophy
- striae
- miliaria
Pharmacology
- Half-life: 8-12h
- Metabolism: liver primarily; CYP450
- Excretion: urine
- Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects