Hypercalcemia: Difference between revisions

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*High >10.5 meq/L (>2.7 ionized)
*High >10.5 meq/L (>2.7 ionized)
*High! >12.0 meq/L
*High! >12.0 meq/L
*90% of cases assoc w/ malignancy or hyperparathyroidism
*90% of cases associated with malignancy or hyperparathyroidism
*Symptoms most correlated w/ rate of rise of Ca, not absolute level
*Symptoms most correlated with rate of rise of Ca, not absolute level


==Clinical Features==
==Clinical Features==
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{{Hypercalcemia DDX}}
{{Hypercalcemia DDX}}


==Diagnosis==
==Evaluation==
===Work-Up===
===Work-Up===
*Calcium
*Calcium
*Phosphate
*Phosphate, Magnesium
*PTH
*Lipase
*Lipase
*UA
*[[Urinalysis]]
*ECG
*[[ECG]]
*Ionized Ca
*Ionized Ca


===ECG Findings===
===[[ECG]] Findings===
*Prolonged PR & QRS
*Prolonged PR & QRS
*Depressed ST
*Widened T waves
*Widened T waves
*Bradyarrhythmias / heart block
*[[bradycardia|Bradyarrhythmia]]s / [[heart block]]
*[[Short QT]]
*[[Short QT]]
*STE/STD, can mimic [[Myocardial Infarction]]<ref>Littmann L, Taylor L 3rd, Brearley WD Jr. ST-segment elevation: a common finding in severe hypercalcemia. J Electrocardiol. 2007 Jan;40(1):60-2.</ref>


==Treatment==
==Management==
{{Hypercalcemia treatment}}
{{Hypercalcemia treatment}}


==Disposition==
==Disposition==
*Ca <12
{| {{table}}
**Home with f/u
| align="center" style="background:#f0f0f0;"|'''Calcium'''
*Ca 12-14  
| align="center" style="background:#f0f0f0;"|'''Disposition'''
**Depends
|-
*Ca>14
| <12||Home with follow up
**No ECG changes: Admit ward
|-
**ECG changes: Admit telemetry
| 12-14||Depends
|-
| >14||
*No [[ECG]] changes: Admit ward  
*[[ECG]] changes: Admit telemetry
|}


==See Also==
==See Also==
*[[Hypercalcemia of Malignancy]]
*[[Hypercalcemia of Malignancy]]


==References ==
==References==
<references/>
<references/>


[[Category:FEN]]
[[Category:FEN]]

Revision as of 14:30, 19 October 2019

Background

  • High >10.5 meq/L (>2.7 ionized)
  • High! >12.0 meq/L
  • 90% of cases associated with malignancy or hyperparathyroidism
  • Symptoms most correlated with rate of rise of Ca, not absolute level

Clinical Features

Symptoms of hypercalcemia

Mnemonic: Stones, Bones, Groans, Moans, Thrones, Psychic Overtones

Differential Diagnosis

Causes of Hypercalcemia

Evaluation

Work-Up

  • Calcium
  • Phosphate, Magnesium
  • PTH
  • Lipase
  • Urinalysis
  • ECG
  • Ionized Ca

ECG Findings

Management

Asymptomatic or Ca <12 mg/dL

  • Does not require immediate treatment
  • Advise to avoid factors that can aggravate hypercalcemia (thiazide diuretics, Li, volume depletion, prolonged inactivity, high Ca diet)

Mildly symptomatic Ca 12-14 mg/dL

  • May not require immediate therapy; however, an acute rise may cause symptoms necessitating treatment as described for severe hypercalcemia (see below)

Symptomatic or Severe hypercalcemia (Ca >14 mg/dL)

  • Patients are likely dehydrated and require saline hydration as initial therapy

Hydration

  • Isotonic saline at 200-300 mL/hour; adjust to maintain urine output at 100-150 mL/hour

Calcitonin

  • Consider adding calcitonin 4 units/kg SC or IV q12hr in patients w/ Ca >14 mg/dL (3.5 mmol/L) who are also symptomatic (lowers Ca w/in 2-4hr)
  • Tachyphylaxis limits use long term, but is a great choice for emergent cases

Bisphosphonates

Give for severe hypercalcemia due to excessive bone resorption (lowers Ca within 12-48hr)[≥12 mg/dL][≥3 mmol/L][2]

  • Pamidronate 90mg IV over 24 hours OR
  • Zoledronate 4mg IV over 15 minutes
  • Caution in renal failure, though bisphosphonates have been safely used in pts with pre-existing renal failure[3]

Electrolyte Repletion

Diuresis

  • Furosemide is NOT routinely recommended
  • Only consider in patients with renal insufficiency or heart failure and volume overload

Dialysis

Consider if patient:

  • Anuric with renal failure
  • Failing all other therapy
  • Severe hypervolemia not amenable to diuresis
  • Serum Calcium level >18mg/dL
  • Neurologic symptoms
  • Heart failure with reduced ejection fraction (unable to provide fluids)

Corticosteroids

Decrease Ca mobilization from bone and are helpful with steroid-sensitive tumors (e.g. lymphoma, MM)

Disposition

Calcium Disposition
<12 Home with follow up
12-14 Depends
>14
  • No ECG changes: Admit ward
  • ECG changes: Admit telemetry

See Also

References

  1. Littmann L, Taylor L 3rd, Brearley WD Jr. ST-segment elevation: a common finding in severe hypercalcemia. J Electrocardiol. 2007 Jan;40(1):60-2.
  2. Shane et al. Uptodate: Treatment of Hypercalcemia. https://www.uptodate.com/contents/treatment-of-hypercalcemia#disclaimerContent
  3. LeGrand SB et al. Narrative Review: Furosemide for Hypercalcemia: An Unproven yet Common Practice. Ann Intern Med. 2008;149:259-263.