Hypertensive emergency: Difference between revisions

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===Etiology===
===Etiology===
*Idiopathic
*Idiopathic
*Sympathomimetic drug use
*[[Sympathomimetic]] drug use
*Preeclampsia
*[[Preeclampsia]]
*Acute glomerulonephritis
*Acute [[glomerulonephritis]]


===Prehospital===
===Prehospital===
*Prehospital BP measurements should be considered reliable<ref>Cienki JJ, DeLuca LA. Agreement between emergency medical services and expert blood pressure measurements. J. Emerg Med. 2012;43(1):64-68.</ref>
*Prehospital BP measurements should be considered reliable<ref>Cienki JJ, DeLuca LA. Agreement between emergency medical services and expert blood pressure measurements. J. Emerg Med. 2012;43(1):64-68.</ref>
*Acute lowering of BP is not typically recommended
*Acute lowering of BP is not typically recommended
*Focus on ABCs (assess need for [[Intubation]] or [[BiPAP|respiratory support]])
*Focus on ABCs (assess need for [[intubation]] or [[BiPAP|respiratory support]])
*Provide care of treatable etiologies
*Provide care of treatable etiologies
**[[CHF]]
**[[CHF]]
**Respiratory Failure from [[Pulmonary Edema]]
**[[Respiratory failure]] from [[pulmonary edema]]
**Acute Pain
**Acute pain


==Clinical Features==
==Clinical Features==
'''End-Organ Dysfunction<ref>Levy PD. Hypertensive Emergencies — On the Cutting Edge. EMCREG - International. 2011. 19-26.</ref>'''
'''End-Organ Dysfunction<ref>Levy PD. Hypertensive Emergencies — On the Cutting Edge. EMCREG - International. 2011. 19-26.</ref>'''
*Brain - Hypertensive encephalopathy, [[seizure]], [[ICH]], ischemic [[stroke]], Confusion
*Acute kidney injury
*Eyes - Retinal hemorrhage, papilledema, Blurred vision
**Often with microscopic hematuria
*Heart - [[ACS]], [[CHF]]/LV failure/[[pulmonary edema]]
*Pulmonary edema
*Vascular - [[Dissection]], Microangiopathic hemolytic anemia
*Type-II myocardial infarction
*Renal - [[Acute renal failure|Acute failure]], [[hematuria]], [[proteinuria]], [[Glomerulonephritis]]
*Hypertensive encephalopathy
*OBGYN - [[Eclampsia]]
**Visual disturbances
**Seizure
**Delirium


==Differential Diagnosis==
==Differential Diagnosis==
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==Evaluation==
==Evaluation==
===Workup===
''Consider any of the following based on the patient's clinical presentation''<ref>2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens. 2013;31(10):1925-1938.</ref>
''Consider any of the following based on the patient's clinical presentation''<ref>2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens. 2013;31(10):1925-1938.</ref>
*CBC - assess for hemolytic anemia
*CBC with peripheral smear- assess for microangiopathic hemolytic anemia
*Chem 8 - assess renal failure and possible secondary causes
*Chem 8 - assess renal failure and possible secondary causes
*Cardiac enzymes
*[[Troponin|Cardiac enzymes]]
*[[Urinalysis]] - Assess renal failure, glomerulonephritis, preeclampsia
*[[Urinalysis]] - Assess renal failure, glomerulonephritis, preeclampsia
*Chest Xray - evaluate for pulmonary edema or dissection
*[[CXR]] - evaluate for pulmonary edema or dissection
*[[ECG]] - LVH, ischemia
*[[ECG]] - [[LVH]], [[myocardial ischemia|ischemia]]
*[[CT head]] - in hypertensive encephalopathy, may not show acute hemorrhage or other acute pathology
**Hypertensive encephalopathy is thought to be secondary to alteration in cerebral auto-regulation leading to [[posterior reversible encephalopathy syndrome]] (now called reversible posterior leukoencephalopathy). Most patients will show changes on MRI, although this is not necessarily indicated in the emergency department.


==Treatment==
===Diagnosis===
*Goal: Lower diastolic pressure to 105 mmHg within 2-6 hours
*Must have evidence of end-organ dysfunction
**''High blood pressure without symptoms is NOT hypertensive emergency (see [[asymptomatic hypertension]])''
**''Symptoms such as headache,epistaxis and dizziness are not evidence of acute end-organ damage and they are not indication for acute BP reduction''
 
==Management==
*Goal: Lower diastolic pressure to 100 mmHg within 2-6 hours
**Maximum initial fall in BP should not exceed 25% of presenting value in 1st hour
**Maximum initial fall in BP should not exceed 25% of presenting value in 1st hour
*Be careful of lowering BP in patients with [[CVA]]
*Be careful of lowering BP in patients with [[CVA]]
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0.3-0.5 mcg/kg/min IV initial infusion
0.3-0.5 mcg/kg/min IV initial infusion


Incr by 0.5mcg/kg/min up to 2mcg/kg/min
Increase by 0.5 mcg/kg/min up to 2mcg/kg/min




| Arterial > veno-dilator
| Arterial > venodilator
|  
|  
1. Very effective
1. Very effective
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2. Coronary steal?
2. Coronary steal?


3. Incr HR
3. Increased HR


|  
|  
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2. Increases coronary flow
2. Increases coronary flow


| Causes Tachycardia
| Causes tachycardia
|  
|  
Drug of choice in patients with cardiac ischemia,
Drug of choice in patients with cardiac ischemia,
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| [[Labetalol]]
| [[Labetalol]]
|  
|  
20-80mg IV bolus q10min OR
20-80mg IV bolus q10 min '''OR'''


0.5-2mg/min IV infusion or
0.5-2 mg/min IV infusion or


200mg to 400mg PO BID
200mg to 400mg PO BID


| Beta>alpha blocker
| Beta>α-blocker
|  
|  
1. No change in HR, cerebral flow
1. No change in HR, cerebral flow
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| [[Esmolol]]
| [[Esmolol]]
|  
|  
Load 250-500&nbsp;mg/kg/ over 2min
Load 250-500 mcg/kg over 2min


Infuse 50mcg/kg/min over 4min
Infuse 50 mcg/kg/min over 4min


- if ineffective repeat load, increase infusion rate by &nbsp;50mcg/kg/min up to 200mcg/kg/min
- if ineffective repeat load, increase infusion rate by &nbsp;50mcg/kg/min up to 300mcg/kg/min


| Beta selective
| Beta selective
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| [[Phentolamine]]
| [[Phentolamine]]
|  
|  
5-10mg IV bolus q5-15min OR
5-15mg IV bolus q5-15min '''OR'''


0.2-5mg/min IV infusion
0.2-0.5mg/min IV infusion


| Alpha blocker
| α-blocker
|  
|  
|  
|  
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2. Avoid in pregnancy
2. Avoid in pregnancy
|-
| [[Clonidine]]
|
0.1 - 0.3 mg PO q12 scheduled; For hypertensive emergency, 0.2 mg x1, then 0.1 mg q1 hr PRN, max 0.6 mg total
| α-2 agonist, BP effects within 30-60 min after PO dose
|
|
| Reduced CNS sympathetic flow, decreasing SVR, HR, BP; no renal blood flow changes; tolerance/tachyphylaxis develop quickly
|-
| [[Hydralazine]]
|
10 - 20 mg slow IV/IM bolus q4-6 hr PRN, max 40 mg/dose
| Peripheral vasodilator, with fall in BP beginning within 30 min, lasting 2-4 hrs
|
|
| Decrease in DBP > SBP; has increased HR, stroke volume and cardiac outpt; preferential vasodilation > venodilation


|}
|}
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*Avoid volume depletion
*Avoid volume depletion
*Prevent reflex tachycardia
*Prevent reflex tachycardia
**Labetolol alone
**Labetalol alone
**Nitroprusside or nicardipine AFTER metoprolol or esmolol
**Nitroprusside or nicardipine AFTER metoprolol or esmolol


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*[[Benzos]]
*[[Benzos]]
*Mixed alpha + B blockade
*Mixed α + B blockade
**Phentolamine OR nitroprusside AND beta blocker
**Phentolamine '''OR''' nitroprusside AND β-blocker


====[[Renal Failure]]====
====[[Renal Failure]]====
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*Magnesium
*Magnesium


====Encephalopathy====
====[[Hypertensive emergency]]====
 
*Decrease MAP by 15-20%
*Decrease MAP by 15-20%
**Avoid overly aggressive lowering
**Avoid overly aggressive lowering
*Nicardipine or labetalol
*[[Nicardipine]] or [[labetalol]]


====[[CVA]]====
====[[CVA]]====


*SAH
*[[SAH]]
**See [[Subarachnoid Hemorrhage (SAH)]]
**See [[Subarachnoid Hemorrhage (SAH)]]
*[[ICH]]
*[[ICH]]
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**[[Labetalol]] or [[Nicardipine]] or [[Esmolol]]
**[[Labetalol]] or [[Nicardipine]] or [[Esmolol]]
*[[Stroke (Main)|Ischemic]]
*[[Stroke (Main)|Ischemic]]
**If thrombolytic treatment is planned then goal systolic blood pressure 185 mm Hg<ref>Acute Stroke Practice Guidelines for Inpatient Management of Ischemic  
**If thrombolytic treatment is planned then goal systolic blood pressure 185 mm Hg and diastolic blood pressure 110 mm Hg<ref>Acute Stroke Practice Guidelines for Inpatient Management of Ischemic  
Stroke and Transient Ischemic Attack (TIA) https://www.heart.org/idc/groups/heart-public/@wcm/@private/@hcm/documents/downloadable/ucm_309996.pdf</ref>
Stroke and Transient Ischemic Attack (TIA) https://www.heart.org/idc/groups/heart-public/@wcm/@private/@hcm/documents/downloadable/ucm_309996.pdf</ref>
**If no thrombolytics then consider blood pressure control if SBP >220 mmHg or DBP >120 mmgHg
**If no thrombolytics then consider blood pressure control if SBP >220 mmHg or DBP >120 mmgHg
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====[[Pheochromocytoma]]====
====[[Pheochromocytoma]]====
*Phentolamine OR (nitroprusside AND beta blocker)
*Phentolamine '''OR''' (nitroprusside AND β-blocker)


==See Also==
==See Also==

Revision as of 00:03, 6 June 2020

High blood pressure without symptoms is NOT hypertensive emergency (see asymptomatic hypertension)

Background

  • Definition: end-organ damage due to hypertension
    • Blood pressure is generally >180/120 (usually > 220/130), but presence of end-organ damage defines disease (not absolute blood pressure number)

Etiology

Prehospital

Clinical Features

End-Organ Dysfunction[2]

  • Acute kidney injury
    • Often with microscopic hematuria
  • Pulmonary edema
  • Type-II myocardial infarction
  • Hypertensive encephalopathy
    • Visual disturbances
    • Seizure
    • Delirium

Differential Diagnosis

Hypertension

Evaluation

Workup

Consider any of the following based on the patient's clinical presentation[3]

  • CBC with peripheral smear- assess for microangiopathic hemolytic anemia
  • Chem 8 - assess renal failure and possible secondary causes
  • Cardiac enzymes
  • Urinalysis - Assess renal failure, glomerulonephritis, preeclampsia
  • CXR - evaluate for pulmonary edema or dissection
  • ECG - LVH, ischemia
  • CT head - in hypertensive encephalopathy, may not show acute hemorrhage or other acute pathology
    • Hypertensive encephalopathy is thought to be secondary to alteration in cerebral auto-regulation leading to posterior reversible encephalopathy syndrome (now called reversible posterior leukoencephalopathy). Most patients will show changes on MRI, although this is not necessarily indicated in the emergency department.

Diagnosis

  • Must have evidence of end-organ dysfunction
    • High blood pressure without symptoms is NOT hypertensive emergency (see asymptomatic hypertension)
    • Symptoms such as headache,epistaxis and dizziness are not evidence of acute end-organ damage and they are not indication for acute BP reduction

Management

  • Goal: Lower diastolic pressure to 100 mmHg within 2-6 hours
    • Maximum initial fall in BP should not exceed 25% of presenting value in 1st hour
  • Be careful of lowering BP in patients with CVA

By Drug

Drug Dose Mechanism Pros Cons Notes
Nitroprusside

0.3-0.5 mcg/kg/min IV initial infusion

Increase by 0.5 mcg/kg/min up to 2mcg/kg/min


Arterial > venodilator

1. Very effective

2. Immediate onset/offset

1. Cyanide Toxicity

2. Coronary steal?

3. Increased HR

1. Avoid in liver/renal failure

2. Avoid with increased ICP

3. Avoid in pregnancy

Nitroglycerin Start 5-100 mcg/min Veno>arteriodilation

1. Rapid on/offset

2. Increases coronary flow

Causes tachycardia

Drug of choice in patients with cardiac ischemia,

LV dysfunction, or pulmonary edema

Labetalol

20-80mg IV bolus q10 min OR

0.5-2 mg/min IV infusion or

200mg to 400mg PO BID

Beta>α-blocker

1. No change in HR, cerebral flow 2. Rapid onset

Avoid in COPD, CHF and heart block

1. Consider in ACS 2. Consider in ischemic CVA

Esmolol

Load 250-500 mcg/kg over 2min

Infuse 50 mcg/kg/min over 4min

- if ineffective repeat load, increase infusion rate by  50mcg/kg/min up to 300mcg/kg/min

Beta selective Rapid on/offset

Avoid in COPD, CHF

bradycardia

Consider in ACS

Nicardipine

Start 5mg/h

If ineffective after 15min increased in 2.5mg/hr interval up to 15mg/hr

Decreases PVR

Good for intracranial pathology Slower onset/offset Avoid in CHF, ACS
Phentolamine

5-15mg IV bolus q5-15min OR

0.2-0.5mg/min IV infusion

α-blocker Used for catecholamine-induced hypertension
Enalaprilat Bolus 1.25mg over 5min q6hr, titrate at 30min intervals to max of 5mg q6hr Decreases HR, SV, systemic arterial pressure Does not impair cerebral flow Variable response

1. Used in patients at risk for cerebral hypotension, CHF

2. Avoid in pregnancy

Clonidine

0.1 - 0.3 mg PO q12 scheduled; For hypertensive emergency, 0.2 mg x1, then 0.1 mg q1 hr PRN, max 0.6 mg total

α-2 agonist, BP effects within 30-60 min after PO dose Reduced CNS sympathetic flow, decreasing SVR, HR, BP; no renal blood flow changes; tolerance/tachyphylaxis develop quickly


Hydralazine

10 - 20 mg slow IV/IM bolus q4-6 hr PRN, max 40 mg/dose

Peripheral vasodilator, with fall in BP beginning within 30 min, lasting 2-4 hrs Decrease in DBP > SBP; has increased HR, stroke volume and cardiac outpt; preferential vasodilation > venodilation


By Disease

Aortic Dissection

  • Rapidly reduce sys BP to 100-120; HR 60-80 within 20min
  • Avoid volume depletion
  • Prevent reflex tachycardia
    • Labetalol alone
    • Nitroprusside or nicardipine AFTER metoprolol or esmolol

Pulmonary Edema

  • Reduce BP by 20-30%
  • Promote diuresis AFTER vasodilation

ACS

  • No more than 20-30% reduction for SBP >160
  • Consider NTG, beta-blocker

Cocaine/Amphetamine Toxicitiy

  • Benzos
  • Mixed α + B blockade
    • Phentolamine OR nitroprusside AND β-blocker

Renal Failure

  • Reduce BP by no more than 20%
  • Avoid nitroprusside (renal metabolism)
  • Labetalol or nicardipine

Eclampsia/Pre-eclampsia

  • Goal BP <160/110
  • Labetalol or nicardipine
  • Magnesium

Hypertensive emergency

CVA

Pheochromocytoma

  • Phentolamine OR (nitroprusside AND β-blocker)

See Also

Video

{{#widget:YouTube|id=KknXoRngPQM}}

References

  1. Cienki JJ, DeLuca LA. Agreement between emergency medical services and expert blood pressure measurements. J. Emerg Med. 2012;43(1):64-68.
  2. Levy PD. Hypertensive Emergencies — On the Cutting Edge. EMCREG - International. 2011. 19-26.
  3. 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens. 2013;31(10):1925-1938.
  4. Acute Stroke Practice Guidelines for Inpatient Management of Ischemic Stroke and Transient Ischemic Attack (TIA) https://www.heart.org/idc/groups/heart-public/@wcm/@private/@hcm/documents/downloadable/ucm_309996.pdf