Revision as of 22:45, 7 March 2021 by Elcatracho (talk | contribs) (→‎Adult Dosing)
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  • Type: NSAID
  • Dosage Forms: Tablets: 100, 200, 400, 600, 800 mg. Suspension: 20mg/ml, 40 mg/ml
  • Common Trade Names: Advil; Motrin

Adult Dosing

  • 800mg PO Q8hours
    • 400mg has been shown to be as effective at pain reduction as 600mg and 800mg[1]

Pediatric Dosing

  • 10mg/kg PO Q6hours
  • Max: 40mg/kg/day

Special Populations

  • Pregnancy Rating: C (1st-2nd trimester), D (3rd trimester)
  • Lactation risk categories: L4; enters breast milk, decreases milk supply
  • Renal Dosing
    • Adult: no adjustment
    • Pediatric: no adjustment
  • Hepatic Dosing
    • Adult: not defined
    • Pediatric: not defined


  • Allergy to class/drug
  • Cardiovascular
    • May cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal
    • Contraindicated for treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
  • Gastrointestinal risk
    • Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
      • Elderly patients are at greater risk for serious GI events.

Adverse Reactions




  • Half-life: 1.8 - 2 hr
  • Metabolism: liver
  • Excretion: Urine
  • Mechanism of Action: exact mechanism unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

See Also


  1. Motov S, Masoudi A, Drapkin J, et al. Comparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2019;74(4):530-537. doi:10.1016/j.annemergmed.2019.05.037