Ibutilide

General

• Type: Antiarrhythmics
• Dosage Forms:IV 1mg/10mL
• Common Trade Names: Corvert

Adult Dosing

• Loading dose = 1mg IV in 50mL D5W over 10min (wt>60kg)
• Loading dose = 0.01mg/kg IV in 50mL D5W over 10min (wt<60kg)
• Dose may be repeated 10min after completion of 1st dose

Pediatric Dosing

Safety/efficacy not established

Special Populations

• Pregnancy Rating: Use in pregnancy may be considered, but data is sparse
• Lactation risk: Not recoemmended
• Renal Dosing: none
• Hepatic Dosing: none

Indications

• Rapid conversion of recent-onset A-fib/flutter to NSR

Contraindications

• Allergy to class/drug

Adverse Reactions

• QT prolongation, V-tach, torsades
• Observe for 4hr after infusion

Pharmacology

• Half-life: 2-12h
• Metabolism: Hepatic
• Excretion: Mostly urine
• Mechanism of Action: Class III - Prolongs AP and refractory period

Kinetics

• Onset of action = 20-30min
• Duration of action = 24hr

See Also

• Antiarrhythmics