Imipenem/Cilastatin

General

Adult Dosing

General

  • Fully-susceptible organisms: 500mg IV q6 hours
  • Moderately-susceptible organisms: 1g IV q6-8 hours
  • Max: Lower of 50 mg/kg or 4 g/day

Pediatric Dosing

General[1]

  • 60-100 mg/kg/day IV divided q6 hours
  • First Dose: 10-16.6 mg/kg IV x 1
  • Max: 4000 mg/day

Special Populations

  • Pregnancy: C
  • Lactation: Use caution
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Source

  1. Red Book, 2012