Insulin: Difference between revisions

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{| width="342"
==Types==
| Type
{| class="wikitable"  
| Onset of action (h)
| Peak action
| Effective duration
| Max duration
|-
|-
| colspan="5" | RAPID ACTING
| <u>'''Type'''</u>
| <u>'''Onset of action (h)'''</u>
| <u>'''Peak action'''</u>
| <u>'''Effective duration'''</u>
| <u>'''Max duration'''</u>
|-
|-
|
| colspan="5" | '''RAPID ACTING'''
|-
|  
Lispro
Lispro


(humalog)
(humalog)
| 0.25-0.5 <br />
 
| 0.25-0.5<br/>
| 0.5-1.25
| 0.5-1.25
| 3-4
| 3-4
| 4-6
| 4-6
|-
|-
|
|  
Aspart
Aspart


(novolog)
(novolog)
| 0.25-0.5<br />
 
| 0.25-0.5<br/>
| 0.5-1.25
| 0.5-1.25
| 3-4
| 3-4
| 4-6
| 4-6
|-
|-
|
|  
Glulisine
Glulisine


(apidra)
(apidra)
| 0.25-0.5
| 0.25-0.5
| 0.25-1.25 <br />
| 0.25-1.25<br/>
| 3-4
| 3-4
| 4-6
| 4-6
|-
|-
| colspan="5" | SHORT ACTING<br />
| colspan="5" | '''SHORT ACTING<br/>'''
|-
|-
| Regular
| Regular
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| 6-8
| 6-8
|-
|-
| colspan="5" | INTERMEDIATE ACTING
| colspan="5" | '''INTERMEDIATE ACTING'''
|-
|-
| NPH
| NPH
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| 14-18
| 14-18
|-
|-
| colspan="5" | LONG ACTING
| colspan="5" | '''LONG ACTING'''
|-
|-
|
|  
glargine
glargine


(Lantus)
(Lantus)
| 3-4
| 3-4
| 8-16
| 8-16
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| 20-24
| 20-24
|-
|-
|
|  
detemir
detemir


(Levemir)
(Levemir)
| 3-4
| 3-4
| 6-8
| 6-8
| 14
| 14
| ~20
| ~20
|}  
|}


[[File:Insulin.jpg|thumbnail]]


Type Onset of action (h) Peak action Effective duration Max duration
{{Common Anti-hyperglycemic Drugs and Pharmacology}}
RAPID ACTING
Lispro


(humalog)
==Insulin Sliding Scale==
 
*Dosing depends on the patient's level of insulin resistance.  
0.25-0.5 0.5-1.25 3-4 4-6
*The example sliding scales are for regular insulin with blood glucose (BG) measured in mg/dL
Aspart
 
(novolog)
 
0.25-0.5 0.5-1.25 3-4 4-6
Glulisine
 
(apidra)
 
0.25-0.5 0.25-1.25  3-4 4-6
SHORT ACTING
Regular 0.5-1 2-3 3-6 6-8
INTERMEDIATE ACTING
NPH 2-4 6-10 10-16 14-18
LONG ACTING
glargine
 
(Lantus)
 
3-4 8-16 18-20 20-24
detemir
 
(Levemir)


3-4 6-8 14 ~20
===Low Dose (Renal Insufficiency)===
*BG 150-199: 1 unit bolus Insulin
*BG 200-249: 2 units bolus Insulin
*BG 250-299: 3 units bolus Insulin
*BG 300-349: 4 units bolus Insulin
*BG Over 350: 5 units bolus Insulin


===Medium Dose (Standard)===
*BG 150-199: 1 unit bolus Insulin
*BG 200-249: 3 units bolus Insulin
*BG 250-299: 5 units bolus Insulin
*BG 300-349: 7 units bolus Insulin
*BG Over 350: 8 units bolus Insulin


===High Dose (Severely Insulin Resistant)===
*BG 150-199: 2 unit bolus Insulin
*BG 200-249: 4 units bolus Insulin
*BG 250-299: 7 units bolus Insulin
*BG 300-349: 10 units bolus Insulin
*BG Over 350: 12 units bolus Insulin


==See Also==
*[[Diabetes (Main)]]


[[Category:Drugs]]
[[Category:Pharmacology]]
[[Category:Endocrinology]]

Latest revision as of 07:47, 9 June 2016

Types

Type Onset of action (h) Peak action Effective duration Max duration
RAPID ACTING

Lispro

(humalog)

0.25-0.5
0.5-1.25 3-4 4-6

Aspart

(novolog)

0.25-0.5
0.5-1.25 3-4 4-6

Glulisine

(apidra)

0.25-0.5 0.25-1.25
3-4 4-6
SHORT ACTING
Regular 0.5-1 2-3 3-6 6-8
INTERMEDIATE ACTING
NPH 2-4 6-10 10-16 14-18
LONG ACTING

glargine

(Lantus)

3-4 8-16 18-20 20-24

detemir

(Levemir)

3-4 6-8 14 ~20
Insulin.jpg

Common Anti-hyperglycemic Drugs and Pharmacology

Drug Pharmacology
Onset Peak Duration
Rapid-acting insulin

  • Aspart (Novolog)
  • Lispro (Humalog)
15-30min 1-2h 3-5h
Short-acting insulin

  • Regular
30-60min 2-4h 6-10h
Intermediate-acting insulin

  • NPH (Humulin, Novolin)
1-3h 4-12h 18-24h
Long-acting insulin

  • Glargine (Lantus)
2-4h None 24h
Sulfonylurea

  • Glimepiride
  • Glipizide (Glucotrol)
  • Glyburide (Glycron, Micronase)
2-6h 12-24h

Insulin Sliding Scale

  • Dosing depends on the patient's level of insulin resistance.
  • The example sliding scales are for regular insulin with blood glucose (BG) measured in mg/dL

Low Dose (Renal Insufficiency)

  • BG 150-199: 1 unit bolus Insulin
  • BG 200-249: 2 units bolus Insulin
  • BG 250-299: 3 units bolus Insulin
  • BG 300-349: 4 units bolus Insulin
  • BG Over 350: 5 units bolus Insulin

Medium Dose (Standard)

  • BG 150-199: 1 unit bolus Insulin
  • BG 200-249: 3 units bolus Insulin
  • BG 250-299: 5 units bolus Insulin
  • BG 300-349: 7 units bolus Insulin
  • BG Over 350: 8 units bolus Insulin

High Dose (Severely Insulin Resistant)

  • BG 150-199: 2 unit bolus Insulin
  • BG 200-249: 4 units bolus Insulin
  • BG 250-299: 7 units bolus Insulin
  • BG 300-349: 10 units bolus Insulin
  • BG Over 350: 12 units bolus Insulin

See Also