Itraconazole

Administration

• Type: Antifungal
• Dosage Forms: Capsule, solution (for oropharyngeal/esophageal candida)
• Routes of Administration:
• Common Trade Names:

Adult Dosing

• 200mg PO 1-4 times per day

Pediatric Dosing

• > 5y: 2.5-10mg/kg 2-3 times per day

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk cannot be ruled out

Renal Dosing

• Adult: No adjustment
• Pediatric:

Hepatic Dosing

• Adult: No adjustment
• Pediatric:

Contraindications

• Allergy to class/drug
• Concomitant use of CYP3A4 substrates (e.g. ergots, lurasidone, methadone, oral midazolam, simvastatin, ticagrelor, and triazolam)
• Ventricular dysfunction (relative)

Adverse Reactions

Serious

• CHF, pulmonary edema
• Hepatotoxicity
• SJS/TEN
• Pancreatitis

Common

• Nausea/vomiting, diarrhea, abdominal pain
• Headache, dizziness
• Edema
• Pruritus, rash
• URI symptoms

Pharmacology

• Half-life: 32-96h
• Metabolism: Hepatic, P450 CYP3A4
• Excretion: Urine, Feces

Mechanism of Action

• Inhibits synthesis of ergosterol (fungal cell membrane component)