Difference between revisions of "Levamisole toxicity"

(Management)
(Management)
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==Management==
 
==Management==
 
*Aggressive supportive care
 
*Aggressive supportive care
 +
*Burn care if significant necrosis
  
 
==Disposition==
 
==Disposition==

Revision as of 03:39, 29 October 2014

Background

  • an antihelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives that has been withdrawn from the U.S. and Canadian markets, due to the risk of serious side effects
  • Increasingly used as a cutting agent in cocaine sold around the globe
  • Results in Levamisole induced necrosis syndrome[1]

Clinical Features

  • agranulocytosis
    • neutropenia
  • levamisole induced necrosis syndrome
    • Necrotic patches anywhere on skin (especially ears and legs)

Differential Diagnosis

Workup

Management

  • Aggressive supportive care
  • Burn care if significant necrosis

Disposition

See Also

External Links

Sources