Difference between revisions of "Levamisole toxicity"

(Disposition)
(Management)
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==Management==
 
==Management==
*Aggressive supportive care
+
*Neutropenia
*Burn care if significant necrosis
+
**Consider neupogen
 +
**Observation for [[neutropenic fever]]
 +
*Necrosis
 +
**Aggressive supportive care
 +
**Burn care if significant necrosis
  
 
==Disposition==
 
==Disposition==

Revision as of 03:56, 29 October 2014

Background

  • an antihelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives that has been withdrawn from the U.S. and Canadian markets, due to the risk of serious side effects
  • Increasingly used as a cutting agent in cocaine sold around the globe
  • Results in Levamisole induced necrosis syndrome[1]

Clinical Features

  • agranulocytosis
    • neutropenia
  • levamisole induced necrosis syndrome
    • Necrotic patches anywhere on skin (especially ears and legs)

Differential Diagnosis

Workup

  • CBC

Management

  • Neutropenia
  • Necrosis
    • Aggressive supportive care
    • Burn care if significant necrosis

Disposition

Admission

See Also

External Links

Sources