Difference between revisions of "Levamisole toxicity"

(Background)
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==Background==
 
==Background==
*an antihelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives that has been withdrawn from the U.S. and Canadian markets, due to the risk of serious side effects  
+
*an antihelminthic and immunomodulator that has been withdrawn from the U.S. and Canadian markets, due to the risk of serious side effects  
 
*Increasingly used as a cutting agent in cocaine sold around the globe
 
*Increasingly used as a cutting agent in cocaine sold around the globe
 
*Results in Levamisole induced necrosis syndrome<ref>http://www.ncbi.nlm.nih.gov/pubmed/20668440</ref>
 
*Results in Levamisole induced necrosis syndrome<ref>http://www.ncbi.nlm.nih.gov/pubmed/20668440</ref>

Revision as of 08:54, 29 October 2014

Background

  • an antihelminthic and immunomodulator that has been withdrawn from the U.S. and Canadian markets, due to the risk of serious side effects
  • Increasingly used as a cutting agent in cocaine sold around the globe
  • Results in Levamisole induced necrosis syndrome[1]

Clinical Features

  • agranulocytosis
    • neutropenia
  • levamisole induced necrosis syndrome
    • Necrotic patches anywhere on skin (especially ears and legs)

Differential Diagnosis

Workup

  • CBC

Management

  • Neutropenia
  • Necrosis
    • Aggressive supportive care
    • Burn care if significant necrosis

Disposition

Admission

See Also

External Links

Sources