Levamisole toxicity: Difference between revisions
| Line 16: | Line 16: | ||
==Management== | ==Management== | ||
*Aggressive supportive care | *Neutropenia | ||
*Burn care if significant necrosis | **Consider neupogen | ||
**Observation for [[neutropenic fever]] | |||
*Necrosis | |||
**Aggressive supportive care | |||
**Burn care if significant necrosis | |||
==Disposition== | ==Disposition== | ||
Revision as of 03:56, 29 October 2014
Background
- an antihelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives that has been withdrawn from the U.S. and Canadian markets, due to the risk of serious side effects
- Increasingly used as a cutting agent in cocaine sold around the globe
- Results in Levamisole induced necrosis syndrome[1]
Clinical Features
- agranulocytosis
- neutropenia
- levamisole induced necrosis syndrome
- Necrotic patches anywhere on skin (especially ears and legs)
Differential Diagnosis
Workup
- CBC
Management
- Neutropenia
- Consider neupogen
- Observation for neutropenic fever
- Necrosis
- Aggressive supportive care
- Burn care if significant necrosis
Disposition
Admission