View source for Lorazepam

==General==
*Type: [[Benzodiazepine]]
*Dosage Forms: Tablet: 0.5, 1, 2 mg. IV solution: 2mg/ml, 4 mg/ml
*Common Trade Names: Ativan

==Adult Dosing==
*Active [[Seizure]]
**2mg IV or IM

==Pediatric Dosing==
Seizure 
* 0.1 mg/kg IV

==Special Populations<ref>Lorazepam: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. </ref>==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*Lactation:
** Lorazepam is present in breast milk 
*Renal Dosing
**Adult
*** PO: no adjustment necessary
*** IV: 
**** Mild to moderate impairment
***** No adjustment necessary
**** Severe impairment
***** Use not recommended
**Pediatric
*** PO: not defined
*** IV:
**** Mild to moderate impairment
***** No adjustment necessary
**** Severe impairment
***** Use not recommended
*Hepatic Dosing
**Adult
*** PO:
**** Mild to moderate impairment: No adjustment necessary 
**** Severe impairment: May need lower doses, use caution 
*** IV:
**** Mild to moderate impairment: No adjustment necessary
**** Severe impairment: Use not recommended
**Pediatric
*** ≥ 12 years old: No adjustment necessary however use caution with severe hepatic disease

==Contraindications==
*Allergy to class/drug
*Respiratory depression

==Adverse Reactions==
===Serious===
* Respiratory depression
* apnea
* hypotension
* paradoxical CNS stimulation

===Common===
* sedation
* ataxia 
* disinhibition 
* dysarthria

==Pharmacology==
*Half-life: 10-20 hours
*Metabolism: liver
*Excretion: renal
*Mechanism of Action: GABA receptor agonist

==See Also==
*[[Anticonvulsants]]

==References==
<references/>

[[Category:Pharmacology]]
[[Category:Neurology]]