Lyme disease: Difference between revisions

(Text replacement - " pts" to " patients")
(Text replacement - "== " to "==")
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== Background  ==
==Background  ==
[[File:Lyme Disease Risk Map.gif|thumb|National Lyme disease risk map with 4 categories of risk.]]
[[File:Lyme Disease Risk Map.gif|thumb|National Lyme disease risk map with 4 categories of risk.]]
[[File:Ixodes scapularis.jpg|thumb|Ixodes tick]]
[[File:Ixodes scapularis.jpg|thumb|Ixodes tick]]
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*Stages: Early localized infection, early disseminated, and late disseminated
*Stages: Early localized infection, early disseminated, and late disseminated


== Clinical Features ==
==Clinical Features ==
[[File:Erythema migrans - erythematous rash in Lyme disease - PHIL 9875.jpg|thumb|"Classic" bull's-eye rash (i.e. erythema migrans) found in 70%-80% of cases<ref name=CDC-Signs-Symptoms-April-2011>[http://www.cdc.gov/lyme/signs_symptoms/ Signs and Symptoms of Lyme Disease], CDC, page last reviewed: June 16, 2015.</ref>]]
[[File:Erythema migrans - erythematous rash in Lyme disease - PHIL 9875.jpg|thumb|"Classic" bull's-eye rash (i.e. erythema migrans) found in 70%-80% of cases<ref name=CDC-Signs-Symptoms-April-2011>[http://www.cdc.gov/lyme/signs_symptoms/ Signs and Symptoms of Lyme Disease], CDC, page last reviewed: June 16, 2015.</ref>]]
''3 Distinct Stages - Not all patients suffer all stages, and stages may overlap with remiss ions b/w stages''
''3 Distinct Stages - Not all patients suffer all stages, and stages may overlap with remiss ions b/w stages''


===Early Localized Infection (7-14d)===  
===Early Localized Infection (7-14d)===
*Erythema Chronicum Migrans: Occurs at site of tick bite, beginning w/ red macule that expands outward. Starts 3-30 days after bite and occurs in 70-80% of cases
*Erythema Chronicum Migrans: Occurs at site of tick bite, beginning w/ red macule that expands outward. Starts 3-30 days after bite and occurs in 70-80% of cases
*Erythema migrans rash more often without central clearing
*Erythema migrans rash more often without central clearing
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{{Tick borne illnesses DDX}}
{{Tick borne illnesses DDX}}


== Diagnosis ==
==Diagnosis ==


*ELISA if positive obtain confirmatory Western blot  
*ELISA if positive obtain confirmatory Western blot  
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*Arthrocentesis, serologic testing of fluid
*Arthrocentesis, serologic testing of fluid


== Management ==
==Management ==
''No risk when duration of attachment <24 hrs''
''No risk when duration of attachment <24 hrs''


=== Prophylaxis ===
===Prophylaxis ===
*Adult: [[Doxycycline]] 200 mg PO x1  
*Adult: [[Doxycycline]] 200 mg PO x1  
*Child >8: 4 mg/kg up to 200 mg PO x1  
*Child >8: 4 mg/kg up to 200 mg PO x1  
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**[[Penicillin G]], [[Cefotaxime]]
**[[Penicillin G]], [[Cefotaxime]]


===Cardiac Disease===  
===Cardiac Disease===


*Mild (1st degree AV with PR &lt;0.3 sec)  
*Mild (1st degree AV with PR &lt;0.3 sec)  
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*[[Ceftriaxone]]/[[Pen G]] IV
*[[Ceftriaxone]]/[[Pen G]] IV


== Disposition ==
==Disposition ==
===Outpatient===
===Outpatient===
*Early Disease  
*Early Disease  
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*[[Tick Borne Illnesses]]
*[[Tick Borne Illnesses]]


== References ==
==References ==
<references/>
<references/>


[[Category:ID]]
[[Category:ID]]

Revision as of 18:38, 5 July 2016

Background

National Lyme disease risk map with 4 categories of risk.
Ixodes tick
  • Tick Borne - Ixodes black-legged ticks
  • Endemic Areas: NE, E US Coasts
  • Caused by spirochete Borrelia burgdorferi
  • The spirochete Borrelia mayonii has been a new strain implicated in cases in the midwest[1]
  • Peak in May to Aug
  • Stages: Early localized infection, early disseminated, and late disseminated

Clinical Features

"Classic" bull's-eye rash (i.e. erythema migrans) found in 70%-80% of cases[2]

3 Distinct Stages - Not all patients suffer all stages, and stages may overlap with remiss ions b/w stages

Early Localized Infection (7-14d)

  • Erythema Chronicum Migrans: Occurs at site of tick bite, beginning w/ red macule that expands outward. Starts 3-30 days after bite and occurs in 70-80% of cases
  • Erythema migrans rash more often without central clearing
  • Fatigue, low grade fever, migrating arthralgia, lymphadenopathy, headache, N/V, abd pain

Early Disseminated Infection (Days to weeks)

  • Skin-mult annular lesions sparing palm/soles
  • Nervous System-fluctuating meningoencephalitis, HA, N/V, CN palsies (ie 7th-can be bilateral) peripheral neuropathy, radiculopathy
  • Cardiovascular: AV blocks, RBBB, dysrhythmias, LV dysfunction
  • Eye: Conjunctivitis, keratitis, retinal detachment, optic neuritis

Late Disseminated Infection (Months to Years)

  • Arthritis: Monarticular/oligoarticular asymmetric arthritis (large joints-commonly knee)
    • Brief episodes separated with complete remission
    • Migratory pattern may occur
  • Nervous System: Subtle encephalopathy, fatigue, polyneuropathy

Differential Diagnosis

Polyarthritis

Algorithm for Polyarticular arthralgia

Tick Borne Illnesses

Diagnosis

  • ELISA if positive obtain confirmatory Western blot
  • PCR
  • Cultures, serologies
  • LP with lymphocytic pleocytosis, elevated protein, normal glucose, + spirochete antibody, paired serum/CSF serologic tests,PCR
    • Must be performed in patients with neuro findings (facial nerve palsy, meningoencephalitis, etc)
    • CNS Lyme disease will be treated with ceftriaxone
  • Arthrocentesis, serologic testing of fluid

Management

No risk when duration of attachment <24 hrs

Prophylaxis

  • Adult: Doxycycline 200 mg PO x1
  • Child >8: 4 mg/kg up to 200 mg PO x1
  • Give if all of the following are met:
    • Tick is adult/nymphal I. scapularis
    • Tick was attached >36 hours based on degree of engorgement or exposure time
    • Prophylaxis can be given within 72 hrs after time tick was removed
    • Local rate of infection in ticks >20%
    • Doxycycline is not contraindicated
  • Old vaccine has little to no efficacy after 1 year

Early Localized Infection

  • Treat before serologic testing if endemic area if + erythema migrans rash
    • Doxycycline 100 mg PO BID x 14-21 days[3]
      • Also treats human granulocytic ehrlichiosis
    • Amoxicillin 500 mg PO TID x 14-21 days
      • Preferred in pregnant, lactating, children <8
    • Cefuroxime axetil 500 mg PO BID x 14-21 days
    • Macrolides-not first line
  • Jarisch-Herxheimer like reaction can occur in first 24 hrs of treatment (fevers, chills, myalgia, tachycardia)

Early Disemminated

Lyme Meningitis

Cardiac Disease

Arthritis

Disposition

Outpatient

  • Early Disease
  • Late Disease: If chronic neurologic/arthritic manifestations may be able to manage as outpt
  • F/u with PMD, rheum, ID

Admission

  • Lyme carditis-cardiac monitoring
  • Prominent neurologic symptoms for IV antibiotics and further care

See Also

References

  1. ↑ Pritt BS, Mead PS, Johnson DKH, et al.Identification of a novel pathogenic Borrelia species causing Lyme borreliosis with unusually high spirochaetaemia: a descriptive study. Lancet Infectious Disease. Published Online: 05 February 2016.
  2. ↑ Signs and Symptoms of Lyme Disease, CDC, page last reviewed: June 16, 2015.
  3. ↑ Shapiro, E. (2014) ‘Lyme disease’, New England Journal of Medicine, 371(7), pp. 683–684.
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