Difference between revisions of "Magnesium sulfate"

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== Adult Dosing ==
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''See [[critical care quick reference]] for drug doses by weight.''
*Loading dose = 1-2gm in 10mL D5W over 1-2min (cardiac arrest)
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==General==
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*Type: [[Antiarrhythmics]]
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*Dosage Forms: IV
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*Common Trade Names:
 +
 
 +
==Adult Dosing==
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*Loading dose = 1-2gm in 10mL D5W over 1-2min ([[cardiac arrest]])
 
*Loading dose = 1-4gm in 50-100 D5W over 20-60min (spontaneous circulation)
 
*Loading dose = 1-4gm in 50-100 D5W over 20-60min (spontaneous circulation)
  
== Contraindications ==
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===[[Eclampsia]]===
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*Initial: 4 g magnesium sulfate 50% solution (400mg elemental magnesium) to a 10% or 20% solution and give IV over 3 to 4 minutes '''OR''' 5mg IM in each buttock
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*Maintenance: 1 to 2 g/hr IV until paroxysms cease
 +
 
 +
==Pediatric Dosing==
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*[[Torsades]]: 25 to 50mg/kg rapid infusion over several minutes
 +
 
 +
===Cardiac===
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*25-50mg/kg IV x 1
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''See [[critical care quick reference]] for drug doses by weight.''
 +
 
 +
==Special Populations==
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*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D (despite being drug of choice for [[eclampsia]]!)
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*Lactation: infant risk minimal
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*Renal Dosing: for severe renal impairment, max dose 20g/48 hours
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**Adult
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**Pediatric
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*Hepatic Dosing
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**Adult
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**Pediatric
  
== Indications ==
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==Indications==
*Torsades
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*[[Torsades]]
 
*Refractory v-tach/fib (regardless of Mg level)
 
*Refractory v-tach/fib (regardless of Mg level)
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*[[Eclampsia]]
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*[[Hypomagnesemia]]
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*Barium poisoning
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==Contraindications==
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*Allergy to class/drug
  
== Mechanism of Action ==
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==Adverse Reactions==
*Increases vasomotor tone
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===Serious===
*Prolongs AV conduction; prolongs refractoriness
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*[[Hypotension]](rare)
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*Heart block
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*CNS depression
  
== Adverse Drug Rxns ==
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===Common===
*Hypotension (rare)
 
  
== Kinetics ==
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==Pharmacology==
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*Half-life:
 
*Onset of action = Immediate
 
*Onset of action = Immediate
 
*Duration of action = 30min
 
*Duration of action = 30min
 +
*Metabolism:
 +
*Excretion: Renal
 +
 +
===Mechanism of Action===
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*Increases vasomotor tone
 +
*Prolongs AV conduction; prolongs refractoriness
  
 
==See Also==
 
==See Also==
*[[Antiarrhythmics]]
 
 
*[[Hypermagnesemia]]
 
*[[Hypermagnesemia]]
 
*[[Hypomagnesemia]]
 
*[[Hypomagnesemia]]
  
[[Category:Drugs]]
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==References==
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<references/>
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[[Category:Pharmacology]]
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[[Category:FEN]]
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[[Category:Cardiology]]

Latest revision as of 23:05, 22 September 2019

See critical care quick reference for drug doses by weight.

General

Adult Dosing

  • Loading dose = 1-2gm in 10mL D5W over 1-2min (cardiac arrest)
  • Loading dose = 1-4gm in 50-100 D5W over 20-60min (spontaneous circulation)

Eclampsia

  • Initial: 4 g magnesium sulfate 50% solution (400mg elemental magnesium) to a 10% or 20% solution and give IV over 3 to 4 minutes OR 5mg IM in each buttock
  • Maintenance: 1 to 2 g/hr IV until paroxysms cease

Pediatric Dosing

  • Torsades: 25 to 50mg/kg rapid infusion over several minutes

Cardiac

  • 25-50mg/kg IV x 1

See critical care quick reference for drug doses by weight.

Special Populations

  • Pregnancy Rating: D (despite being drug of choice for eclampsia!)
  • Lactation: infant risk minimal
  • Renal Dosing: for severe renal impairment, max dose 20g/48 hours
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Indications

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Onset of action = Immediate
  • Duration of action = 30min
  • Metabolism:
  • Excretion: Renal

Mechanism of Action

  • Increases vasomotor tone
  • Prolongs AV conduction; prolongs refractoriness

See Also

References