Magnesium sulfate

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See critical care quick reference for drug doses by weight.

General

Adult Dosing

  • Loading dose = 1-2gm in 10mL D5W over 1-2min (cardiac arrest)
  • Loading dose = 1-4gm in 50-100 D5W over 20-60min (spontaneous circulation)

Indications

  • Torsades
  • Refractory v-tach/fib (regardless of Mg level)

Pediatric Dosing

Cardiac

  • 25-50 mg/kg IV x 1

See critical care quick reference for drug doses by weight.

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Hypotension (rare)

Common

Pharmacology

  • Half-life:
  • Onset of action = Immediate
  • Duration of action = 30min
  • Metabolism:
  • Excretion:

Mechanism of Action

  • Increases vasomotor tone
  • Prolongs AV conduction; prolongs refractoriness

See Also

References