Metronidazole
General
- Type: Other Antibacterials
- Dosage Forms:
- IV
- PO: 250mg; 375mg; 500mg
- Common Trade Names: Flagyl
Adult Dosing
General
- PO
- 500 mg PO q6-8h x 7-10 days
- First Dose: 500 mg PO x 1
- IV
- 15mg/kg IV x1, then 7.5mg/kg IV q6h
- First Dose: 15mg/kg IV x1
- Max: 1 gram/dose
Pediatric Dosing
General (<1200g)
- 7.5 mg/kg PO/IV q48h
- First Dose: 7.5 mg/kg PO/IV x 1
General (>1200g AND <1 Month Old)
- <7 days old
- 7.5-15 mg/kg/day PO/IV q12-24h
- First Dose: 7.5-15 mg/kg PO/IV x 1
- >7 days old
- 15-30 mg/kg/day PO/IV q12h
- First Dose: 7.5-15 mg/kg PO/IV x 1
General (>1 Month Old)
- 30 mg/kg/day PO/IV q6h
- First Dose: 7.5 mg/kg PO/IV x 1
- Max: 4 g/day
Special Populations
- Pregnancy: B
- Lactation: Safety conditional
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Black Box: carcinogenic in mice and rats; avoid unnecessary use; reserved for approved conditions
- Allergy to class/drug
- Pregnancy (single 2 dose retimen)
- Alcohol use within 3 days
- Disulfram use within 14 days
Adverse Reactions
Serious
- Seizures
- Aseptic meningitis
- Perifpheral neuropathy
- Optic neuropathy
- Encephalopathy
- Hypersensitivity Reaction
- Steven-Johnson Syndrome
- Toxic Epidermal Necrolysis
- Leukopenia
- Carcinogenicity (in animals)
Common
- Nausea and Vomiting
- Epigastric discomfort
- Diarrhea
- Metallic taste
- Rash
- Headache
- Dizziness
- Dark reddish-brown urine
- Candidiasis
- Thrombophlebitis (IV use)
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
See Also
Source
- Epocrates