Myasthenia gravis: Difference between revisions

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==Background==
==Background==
*Autoantibody degradation, dysfunction, and blockade of acetylcholine receptor at the NMJ
*Autoantibody degradation, dysfunction, and blockade of acetylcholine receptor at the NMJ
*Thymus is abnormal in 75% of pts
*Thymus is abnormal in 75% of patients
**Thymectomy resolves or improves symptoms in most pts, especially those with a thymoma
**Thymectomy resolves or improves symptoms in most patients, especially those with a thymoma
*No sensory, reflex, pupillary, or cerebellar deficits
*No sensory, reflex, pupillary, or cerebellar deficits


===Myasthenic Crisis versus Cholinergic Crisis===
===Drugs that may unmask or worsen myasthenia gravis<ref>https://neurology.uams.edu/wp-content/uploads/sites/49/2018/03/Drugs-that-may-worsen-Myasthenia-Gravis.pdf</ref>===
#Myasthenic Crisis
*Antimicrobials ([[Aminoglycosides]], [[clindamycin]], [[erythromycin]], [[tetracycline]], [[doxycycline]], [[azithromycin]], [[fluoroquinolones]], [[vancomycin]], [[chloroquine]], [[hydroxychloroquine]], )<ref> UpToDate Clinical manifestations of myasthenia gravis may 2016</ref>
##Respiratory failure is feared complication
*Cardiovascular drugs ([[beta blockers]], [[procainamide]], [[quinidine]])
##Much more common
*Neuro/psych meds ([[chlorpromazine]], [[lithium]], [[prochlorperazine]], [[phenytoin]], [[risperidone]],  
##D/t med non-compliance, infection, surgery, tapering of immunosuppressants, meds
*Other (Botox, [[quinine]]s, [[magnesium]])
#Cholinergic Crisis
##Excessive anticholinesterase medication may cause weakness and cholinergic symptoms
===Drugs Usually well-tolerated in myasthenia gravis but occasionally associated with an exacerbation===
##Rarely if ever seen w/ dose limitation of pyridostigmine to less than 120mg q3hr
*Local anesthetics
##If on usual dose of meds assume exacerbation due to MG even w/ cholinergic side effects
*Antibiotics ([[Tetracycline]]/[[doxycycline]], [[macrolides]], [[metronidazole]], [[nitrofurantoin]])
#Edrophonium (Tensilon) test to distinguish the two is controversial
*Anticonvulsants ([[carbamazepine]], [[ethosuximide]], [[gabapentin]], [[phenobarbital]], [[phenytoin]])
##Give 1-2 mg IV slow push. If any fasciculations, resp depression, or cholinergic symptoms within a few minutes, problem is likely cholinergic crisis (no more edrophonium). If no evidence of cholinergic excess, give total of 10 mg and observe improvement in case of myasthenic crisis.
*Butyrophenones ([[haloperidol]])
## Side effects of Edrophonium: Arrhythmias, Hypotension, Bronchospasm
*Phenothiazines ([[chlorpromazine]]/[[prochlorperazine]])
## Treatment: Atropine
*[[Calcium channel blockers]]
*[[Steroids]]
*Ophthalmic drugs (betaxolol/timolol/proparacaine)
*Other (Iodinated contrast agent)
 
See also: https://neurology.uams.edu/wp-content/uploads/sites/49/2018/03/Drugs-that-may-worsen-Myasthenia-Gravis.pdf


==Clinical Features==
==Clinical Features==
#Symptoms worsen with repetitive use / as the day progresses
[[File:DiplopiaMG1.jpg|thumb|Cranial nerve palsy and ptosis in a patient with myasthenia gravis]]
##Ice Pack Test- should improve symptoms temporarily (usually ptosis; high specificity)
*Muscle [[weakness]]
#Muscle weakness
**Proximal extremities
##Proximal extremities
**Neck extensors
##Neck extensors
**Facial/bulbar muscles ([[dysphagia]], [[dysarthria]], [[dysphonia]])
##Facial/bulbar muscles (dysphagia, dysarthria, dysphonia)
*Ocular weakness
#Ocular weakness
**Ptosis
##Ptosis
**[[Diplopia]]
##[[Diplopia]]
**[[cranial nerve palsies|CN III, IV, or VI weakness]]
##CN III, IV, or VI weakness
*Symptoms worsen with repetitive use / as the day progresses<ref>Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7e (2010), Chapter 167. Chronic Neurologic Disorders</ref>


==Differential Diagnosis==
==Differential Diagnosis==
===Drug-induced myasthenia===
===Drug-induced myasthenia===
*[[Antibiotics]] ([[aminoglycosides]], [[fluroquinolones]], [[clindamycin]], [[metronidazole]], [[macrolides]])
*[[Antibiotics]] ([[aminoglycosides]], [[fluroquinolones]], [[clindamycin]], [[metronidazole]], [[macrolides]])<ref>Sanders DB, Guptill JT. Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome. Continuum. 2014 Oct;20(5)</ref>
*Steroids
*Steroids
*Anticonvulsants (phenytoin, barbiturates, lithium)
*[[Anticonvulsants]] (phenytoin, barbiturates, lithium)
*Psychotropics (haloperidol)
*Psychotropics ([[haloperidol]])
*Beta-blockers / calcium-channel blockers
*[[Beta-blockers]] / [[calcium-channel blockers]]
*Local anesthetics
*Local anesthetics
*Narcotics
*[[Opioids]]
*Anticholinergics (diphenhydramine)
*[[Anticholinergics]] (diphenhydramine)
*NMJ blocking agents (roc, sux)
*NMJ blocking agents ([[rocuronium]], [[succinylcholine]])


{{Weakness DDX}}
{{Weakness DDX}}


==Treatment==
==Evaluation==
*Always evaluate tidal volume, FEV, negative inspiratory force, ability to handle secretions
[[File:Myasthenia gravis ptosis reversal.jpg|thumb|Right partial ptosis (left picture) with left lid showing compensatory pseudo lid retraction because of equal innervation of the levator palpabrae superioris (Hering's law of equal innervation): Right picture: after an edrophonium test, note the improvement in ptosis.]]
#Meds
[[File:Tumor Thymoma1.jpg|thumb|A chest CT-scan showing a thymoma (red circle).]]
##Pyridostigmine
*Ice Pack Test- should improve symptoms temporarily (usually ptosis; high specificity)
###If pt's usual dose has been missed the next dose is usually doubled
**Place ice-pack on eyes for 2 mins, if ptosis decreases by ≥2mm the test is positive
###PO route: 60-90mg q4hr
*Acetylcholine receptor antibodies (AcHR-Ab). Positive in 80-90% of generalized MG and 40-55% in Ocular MG.
###IV route: 1/30th of the PO dose (2-3mg) by slow IV infusion
 
##Neostigmine
{{Myasthenic vs cholinergic crisis}}
###0.5mg IV
 
#[[Intubation]]
==Management==
##If possible avoid depolarizing AND non-depolarizing agents
Always evaluate:<ref>Emergency Medicine Practice -- Weakness: A systemic approach to acute non-traumatic neurologic and neuromuscular causes Dec 2002</ref>
###If pt requires paralysis use non-depolarizing agent at smaller dose  
*Tidal volume
###If must use depolarizing agents, will need higher doses
*Forced Vital capacity (normal is >25cc/kg in MG)
#Plasmapherisis
*FEV
#IVIG
*Negative inspiratory force (NIF) (normal is -80 to -100 and greater than +20 respiratory support indicated)
*Ability to handle secretions  
 
===Investigations<ref>Myasthenia gravis: Association of British Neurologists’ management guidelines [https://pn.bmj.com/content/15/3/199]</ref>===
*ACh-R antibody testing: first-line investigation. Indication for thymectomy if < 45 years.
**MuSK antibody testing: for patients negative for ACh-R antibodies
*Thyroid function
*Neurophysiology: Repetitive nerve stimulation is the initial test; if negative, consider single-fibre electromyography.
*MR scan of brain: Patients with negative serology and neurophysiology, and symptoms compatible with ocular myasthenia may have structural brain disease.
*Thymus scanning: All patients with suspected myasthenia, irrespective of distribution (ocular/generalised) or serology (seropositive/negative), should undergo thymus imaging. The modality (CT or MRI) should be decided locally.
*Edrophonium/Tensilon test
 
===Medications===
 
[[Pyridostigmine]] and [[neostigmine]] primarily used for symptomatic relief but does not alter course of crisis<ref>Wendell LC and Levine JM. Myasthenic Crisis. Neurohospitalist. 2011 Jan; 1(1): 16–22.</ref>. Consider avoiding pyridostigmine/neostigmine in ICU ventilated patients, as these may increase secretions. Continued use of these meds also prevents assessment of other treatment modalities and can increase muscle weakness if used in excess
*[[Pyridostigmine]]: Titrate up to find the lowest effective dose
**Initially 30 mg four times daily for 2–4 days
**Then 60 mg (1 tablet) four times daily for 5 days and experiment with timing
**Then increase to 90 mg four times daily over 1 week if required.
**If patient's usual dose has been missed the next dose is usually doubled
**IV route: 1/30th of the PO dose (2-3mg) by slow IV infusion
*[[Neostigmine]]
**0.5mg IV
[[Prednisolone]]: If symptomatic despite Pyridostigmine. Monitor diabetes mellitus.
*Ocular myasthenia gravis
**Start 5 mg on alternate days for three doses and increase by 5 mg every three doses until symptoms improve.
**The maximum dose is 50 mg on alternate days or 0.75 mg/kg/alternate day
*Generalised myasthenia gravis
**Start 10 mg on alternate days for three doses and increase by 10 mg every three doses until symptoms improve.
**Maximum dose is 100 mg alternate days or 1.5 mg/kg
[[Plasmapheresis]]
*Effect lasts 15-20 days
[[IVIG]]
*0.4 g/kg/die for 5 days
*Effect lasts 30-45 days
 
In '''Myasthenic Crisis''' :
*Acetylcholinesterase inhibitors are discontinued to avoid excessive bronchial secretions
*[[Intubation]]
**If possible avoid depolarizing AND non-depolarizing agents
**If patient requires paralysis use non-depolarizing agent at smaller dose  
**If must use depolarizing agents, will need higher doses
*IVIG and plasmapheresis
 
==Disposition==
*Typically MICU or neuro ICU, consideration for thymectomy if not done already
*Consideration for [[corticosteroids]] or other immunosuppressants (i.e. corticosteroids, azathioprine, mycophenolate mofetil, cyclosporine)


==See Also==
==See Also==
*[[Lambert-Eaton Myasthenic Syndrome]]
*[[Weakness]]
 
==References==
<references/>


==Source==
*Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7e (2010), Chapter 167. Chronic Neurologic Disorders


[[Category:Neuro]]
[[Category:Neurology]]

Revision as of 18:28, 28 January 2020

Background

  • Autoantibody degradation, dysfunction, and blockade of acetylcholine receptor at the NMJ
  • Thymus is abnormal in 75% of patients
    • Thymectomy resolves or improves symptoms in most patients, especially those with a thymoma
  • No sensory, reflex, pupillary, or cerebellar deficits

Drugs that may unmask or worsen myasthenia gravis[1]

Drugs Usually well-tolerated in myasthenia gravis but occasionally associated with an exacerbation

See also: https://neurology.uams.edu/wp-content/uploads/sites/49/2018/03/Drugs-that-may-worsen-Myasthenia-Gravis.pdf

Clinical Features

Cranial nerve palsy and ptosis in a patient with myasthenia gravis

Differential Diagnosis

Drug-induced myasthenia

Weakness

Evaluation

Right partial ptosis (left picture) with left lid showing compensatory pseudo lid retraction because of equal innervation of the levator palpabrae superioris (Hering's law of equal innervation): Right picture: after an edrophonium test, note the improvement in ptosis.
A chest CT-scan showing a thymoma (red circle).
  • Ice Pack Test- should improve symptoms temporarily (usually ptosis; high specificity)
    • Place ice-pack on eyes for 2 mins, if ptosis decreases by ≥2mm the test is positive
  • Acetylcholine receptor antibodies (AcHR-Ab). Positive in 80-90% of generalized MG and 40-55% in Ocular MG.

Myasthenic versus cholinergic crisis

Flaccid paralysis resulting from cholinergic crisis can be distinguished from myasthenia gravis by the use of the drug edrophonium, which worsens the paralysis caused by cholinergic crisis, but strengthens the muscle in the case of myasthenia gravis. (Edrophonium is an cholinesterase inhibitor hence increases the concentration of acetylcholine present).

  • Myasthenic Crisis
    • Respiratory failure is feared complication
    • Much more common
    • Due to medication non-adherence, infection, surgery, tapering of immunosuppressants, meds
  • Cholinergic Crisis
    • Excessive anticholinesterase medication may cause weakness and cholinergic symptoms
    • Rarely if ever seen with dose limitation of pyridostigmine to less than 120mg q3hr
    • If on usual dose of meds assume exacerbation due to MG even with cholinergic side effects
  • Edrophonium (Tensilon) test to distinguish the two is controversial
    • Give 1-2mg IV slow push. If any fasciculations, respiratory depression, or cholinergic symptoms within a few minutes, problem is likely cholinergic crisis (no more edrophonium). If no evidence of cholinergic excess, give total of 10mg and observe improvement in case of myasthenic crisis.
    • Side effects of Edrophonium: Arrhythmias, Hypotension, Bronchospasm
    • Thus, need to be on a monitor, with atropine on hand
    • Treatment: Atropine

Management

Always evaluate:[5]

  • Tidal volume
  • Forced Vital capacity (normal is >25cc/kg in MG)
  • FEV
  • Negative inspiratory force (NIF) (normal is -80 to -100 and greater than +20 respiratory support indicated)
  • Ability to handle secretions

Investigations[6]

  • ACh-R antibody testing: first-line investigation. Indication for thymectomy if < 45 years.
    • MuSK antibody testing: for patients negative for ACh-R antibodies
  • Thyroid function
  • Neurophysiology: Repetitive nerve stimulation is the initial test; if negative, consider single-fibre electromyography.
  • MR scan of brain: Patients with negative serology and neurophysiology, and symptoms compatible with ocular myasthenia may have structural brain disease.
  • Thymus scanning: All patients with suspected myasthenia, irrespective of distribution (ocular/generalised) or serology (seropositive/negative), should undergo thymus imaging. The modality (CT or MRI) should be decided locally.
  • Edrophonium/Tensilon test

Medications

Pyridostigmine and neostigmine primarily used for symptomatic relief but does not alter course of crisis[7]. Consider avoiding pyridostigmine/neostigmine in ICU ventilated patients, as these may increase secretions. Continued use of these meds also prevents assessment of other treatment modalities and can increase muscle weakness if used in excess

  • Pyridostigmine: Titrate up to find the lowest effective dose
    • Initially 30 mg four times daily for 2–4 days
    • Then 60 mg (1 tablet) four times daily for 5 days and experiment with timing
    • Then increase to 90 mg four times daily over 1 week if required.
    • If patient's usual dose has been missed the next dose is usually doubled
    • IV route: 1/30th of the PO dose (2-3mg) by slow IV infusion
  • Neostigmine
    • 0.5mg IV

Prednisolone: If symptomatic despite Pyridostigmine. Monitor diabetes mellitus.

  • Ocular myasthenia gravis
    • Start 5 mg on alternate days for three doses and increase by 5 mg every three doses until symptoms improve.
    • The maximum dose is 50 mg on alternate days or 0.75 mg/kg/alternate day
  • Generalised myasthenia gravis
    • Start 10 mg on alternate days for three doses and increase by 10 mg every three doses until symptoms improve.
    • Maximum dose is 100 mg alternate days or 1.5 mg/kg

Plasmapheresis

  • Effect lasts 15-20 days

IVIG

  • 0.4 g/kg/die for 5 days
  • Effect lasts 30-45 days

In Myasthenic Crisis :

  • Acetylcholinesterase inhibitors are discontinued to avoid excessive bronchial secretions
  • Intubation
    • If possible avoid depolarizing AND non-depolarizing agents
    • If patient requires paralysis use non-depolarizing agent at smaller dose
    • If must use depolarizing agents, will need higher doses
  • IVIG and plasmapheresis

Disposition

  • Typically MICU or neuro ICU, consideration for thymectomy if not done already
  • Consideration for corticosteroids or other immunosuppressants (i.e. corticosteroids, azathioprine, mycophenolate mofetil, cyclosporine)

See Also

References

  1. https://neurology.uams.edu/wp-content/uploads/sites/49/2018/03/Drugs-that-may-worsen-Myasthenia-Gravis.pdf
  2. UpToDate Clinical manifestations of myasthenia gravis may 2016
  3. Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7e (2010), Chapter 167. Chronic Neurologic Disorders
  4. Sanders DB, Guptill JT. Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome. Continuum. 2014 Oct;20(5)
  5. Emergency Medicine Practice -- Weakness: A systemic approach to acute non-traumatic neurologic and neuromuscular causes Dec 2002
  6. Myasthenia gravis: Association of British Neurologists’ management guidelines [1]
  7. Wendell LC and Levine JM. Myasthenic Crisis. Neurohospitalist. 2011 Jan; 1(1): 16–22.