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Background
Clinical Features
- Palpable splenomegaly
- Bone pain
Differential Diagnosis
Evaluation
Workup
- CBC
- Blood smear
- Chem 7
- Bone marrow biopsy
Diagnosis[1]
- Criteria: The diagnosis of primary myelofibrosis requires meeting all 3 major criteria and 2 minor criteria.
Major criteria
|
Megakaryocyte proliferation and atypia with reticulin and/or collagen fibrosis,
or with increased marrow cellularity, granulocytic proliferation, and decreased erythropoiesis
|
Not meeting WHO criteria for CML, PV, MDS, or other myeloid neoplasm
|
Demonstration of JAK2V617F or other clonal marker or no evidence of reactive bone marrow fibrosis
|
Minor criteria
|
Leukoerythroblastosis
|
Increased serum LDH
|
Anemia
|
Palpable splenomegaly
|
Management
Also See
References
- ↑ Tefferi, A, et al. The 2008 World Health Organization classification system for myeloproliferative neoplasms: order out of chaos. Cancer. 2009; 115(17):3842-7,