Neuromuscular blocking agents: Difference between revisions
(→Types) |
(→Types) |
||
| (9 intermediate revisions by 4 users not shown) | |||
| Line 10: | Line 10: | ||
|+Neuromuscular Blocking Agents | |+Neuromuscular Blocking Agents | ||
!Agent | !Agent | ||
!'''Time to onset''' (seconds) | |||
!'''Duration''' (minutes) | |||
!Side effects | !Side effects | ||
|- | |- | ||
| ''' | | '''Depolarizing''' | ||
|- | |- | ||
|[[Succinylcholine]] | |[[Succinylcholine]] | ||
| Line 22: | Line 21: | ||
|fasciculations, post-operative pain | |fasciculations, post-operative pain | ||
|- | |- | ||
| '''Depolarizing''' | | '''Non-Depolarizing''' | ||
|- | |- | ||
|[[Vecuronium]] (Norcuron) | |[[Vecuronium]] (Norcuron) | ||
| Line 40: | Line 32: | ||
|45–70 | |45–70 | ||
|may promote muscarinic block | |may promote muscarinic block | ||
|- | |- | ||
|[[Pancuronium]] (Pavulon) | |[[Pancuronium]] (Pavulon) | ||
| Line 47: | Line 38: | ||
| | | | ||
*[[tachycardia]] (slight) | *[[tachycardia]] (slight) | ||
(no hypotension) | *(no [[hypotension]]) | ||
|- | |- | ||
|} | |} | ||
== | ==See Also== | ||
*Reversal agent: [[Sugammadex]] | |||
==References== | |||
<references/> | <references/> | ||
[[Category:Pharmacology]] | |||
[[Category:Critical Care]] | |||
Latest revision as of 00:47, 25 February 2020
Background
- Non-depolarizing
- Competitively block binding of ACh to its receptors
- Depolarizing
- Depolarizing skeletal muscle fiber
- Persistent depolarization makes the muscle fiber resistant to further stimulation by ACh
Types
| Agent | Time to onset (seconds) | Duration (minutes) | Side effects |
|---|---|---|---|
| Depolarizing | |||
| Succinylcholine | fasciculations, post-operative pain | ||
| Non-Depolarizing | |||
| Vecuronium (Norcuron) | 60 | 30–40 | Few, may cause prolonged paralysis and promote muscarinic block |
| Rocuronium (Zemuron) | 75 | 45–70 | may promote muscarinic block |
| Pancuronium (Pavulon) | 90 | 180 or more |
|
See Also
- Reversal agent: Sugammadex