Difference between revisions of "Nicardipine"

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==Adult Dosing==
 
==Adult Dosing==
'''Hypertension'''
+
===[[Hypertension]]===
 
*PO: 20-40 mg q8hr, or 30-60mg (extended release) q12hr
 
*PO: 20-40 mg q8hr, or 30-60mg (extended release) q12hr
 
*IV: 5 mg/hr by slow infution (50 ml/hr)
 
*IV: 5 mg/hr by slow infution (50 ml/hr)
 
   
 
   
'''Chronic Stable Angina'''
+
===Chronic Stable Angina===
 
*20-40 mg PO q8hr
 
*20-40 mg PO q8hr
 
*Allow 3 days between dose increase
 
*Allow 3 days between dose increase
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
'''Hypertension'''
+
===Hypertension===
 
*0.5-3 mcg/kg/min IV
 
*0.5-3 mcg/kg/min IV
 
*Not approved by FDA; limited date available
 
*Not approved by FDA; limited date available

Revision as of 06:00, 30 July 2015

General

  • Type: Calcium Channel Blocker
  • Dosage Forms: Capsule, Infusion solution, Injectable solution
  • Common Trade Names: Cardene

Adult Dosing

Hypertension

  • PO: 20-40 mg q8hr, or 30-60mg (extended release) q12hr
  • IV: 5 mg/hr by slow infution (50 ml/hr)

Chronic Stable Angina

  • 20-40 mg PO q8hr
  • Allow 3 days between dose increase

Pediatric Dosing

Hypertension

  • 0.5-3 mcg/kg/min IV
  • Not approved by FDA; limited date available

Special Populations

  • Pregnancy Rating: Category C
  • Lactation: Unknown wether drug is excreted in breast milk; avoid use
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 2-4 hr
  • Metabolism: Metabolized in liver b CYP3A4 (first pass)
  • Excretion: urine (60%), feces (35%)
  • Mechanism of Action:

See Also

Sources