Difference between revisions of "Nicardipine"

(Chronic Stable Angina)
Line 9: Line 9:
*IV: 5 mg/hr by slow infution (50 ml/hr)
*IV: 5 mg/hr by slow infution (50 ml/hr)
===Chronic Stable Angina===
===Chronic [[Stable Angina]]===
*20-40 mg PO q8hr
*20-40 mg PO q8hr
*Allow 3 days between dose increase
*Allow 3 days between dose increase

Revision as of 06:06, 30 July 2015


Adult Dosing


  • PO: 20-40 mg q8hr, or 30-60mg (extended release) q12hr
  • IV: 5 mg/hr by slow infution (50 ml/hr)

Chronic Stable Angina

  • 20-40 mg PO q8hr
  • Allow 3 days between dose increase

Pediatric Dosing


  • 0.5-3 mcg/kg/min IV
  • Not approved by FDA; limited date available

Special Populations

  • Pregnancy Rating: Category C
  • Lactation: Unknown wether drug is excreted in breast milk; avoid use
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric


  • Allergy to class/drug

Adverse Reactions




  • Half-life: 2-4 hr
  • Metabolism: Metabolized in liver b CYP3A4 (first pass)
  • Excretion: urine (60%), feces (35%)
  • Mechanism of Action:
    • inhibits trasmembrane influx of extracellular calcium ions across membranes of myocardial cells and vascular smooth muscle cells without changing serum calcium concentrations; this inhibit cardiac and vascular smooth muscle contractions, thereby dilating maincoronary and systemic arteries.

See Also


  • Medscape