Nicardipine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[Hypertension]]=== | ===[[Hypertension]]=== | ||
*PO: 20- | *PO: 20-40mg q8hr, or 30-60mg (extended release) q12hr | ||
*IV: 5mg/hr by slow infusion (50 ml/hr), titrate to maximum of | *IV: 5mg/hr by slow infusion (50 ml/hr), titrate to maximum of 30mg/hr, then maintenance of 2.0 - 15.5mg/hr | ||
*IV bolus dose of 2mg, then continuous infusion achieves same control of HTN as starting infusion without bolus<ref>Tao P, Zheng DY, Yu XJ. Effects of intravenous nicardipine in Chinese patients with hypertensive emergencies. Curr Ther Res Clin Exp 1998 Mar; 59: 188-95.</ref> | *IV bolus dose of 2mg, then continuous infusion achieves same control of HTN as starting infusion without bolus<ref>Tao P, Zheng DY, Yu XJ. Effects of intravenous nicardipine in Chinese patients with hypertensive emergencies. Curr Ther Res Clin Exp 1998 Mar; 59: 188-95.</ref> | ||
===Chronic [[Stable Angina]]=== | ===Chronic [[Stable Angina]]=== | ||
*20- | *20-40mg PO q8hr | ||
*Allow 3 days between dose increase | *Allow 3 days between dose increase | ||
Revision as of 12:19, 24 July 2016
General
- Type: Calcium Channel Blocker
- Dosage Forms: Capsule, Infusion solution, Injectable solution
- Common Trade Names: Cardene
Adult Dosing
Hypertension
- PO: 20-40mg q8hr, or 30-60mg (extended release) q12hr
- IV: 5mg/hr by slow infusion (50 ml/hr), titrate to maximum of 30mg/hr, then maintenance of 2.0 - 15.5mg/hr
- IV bolus dose of 2mg, then continuous infusion achieves same control of HTN as starting infusion without bolus[1]
Chronic Stable Angina
- 20-40mg PO q8hr
- Allow 3 days between dose increase
Pediatric Dosing
Hypertension
- 0.5-3 mcg/kg/min IV
- Not approved by FDA; limited date available
Special Populations
- Pregnancy Rating: Category C
- Lactation: Unknown wether drug is excreted in breast milk; avoid use
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Headache (IV, 15%)
Common
- Flushing
- Peripheral Edema
- Pedal Edema
- Hypotension
- Exacerbation of angina
Pharmacology
- Half-life: 2-4 hr
- Metabolism: Metabolized in liver b CYP3A4 (first pass)
- Excretion: urine (60%), feces (35%)
- Mechanism of Action:
- inhibits trasmembrane influx of extracellular calcium ions across membranes of myocardial cells and vascular smooth muscle cells without changing serum calcium concentrations; this inhibit cardiac and vascular smooth muscle contractions, thereby dilating maincoronary and systemic arteries.
See Also
References
- ↑ Tao P, Zheng DY, Yu XJ. Effects of intravenous nicardipine in Chinese patients with hypertensive emergencies. Curr Ther Res Clin Exp 1998 Mar; 59: 188-95.