Ofloxacin
General
- Type: Fluroquinolones
- Dosage Forms: 200,300,400
- Common Trade Names: Floxin
Adult Dosing
- infections, bacterial
- 200-400mg PO q12h
- infections, chlamydial
- 300mg PO q12h x 7d
- urethritis, nongonococcal
- 300mg PO q12h x 7d
- epididymitis
- 300mg PO q12h x 10d
- typhoid fever
- 400mg PO q12h x 7-14d
Pediatric Dosing
- PID
- >12yrs: 400mg PO BID x 14d
- typhoid fever
- 20mg/kg BID x 10d, max 400mg/dose
Special Populations
- Pregnancy:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
Source
- ↑ Sanford Guide to Antimicrobial Therapy 2014