Osmolal or Osmolar Gap

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Definitions

  • Osmolarity = the total number of particles in solution per liter
  • Osmolality = the number of particles per kilogram of solvent

Calculations

Calculated Osm

Calculated Osm = 2 x Na + (glu/18) + (BUN/2.8) + (ethanol/4.6) + (methanol/2.6) + (ethylene glycol/5) + (acetone/5.5) + (isopropanol/5.9)

  • Normal = 275-295

Osmolal Gap

Osmolal Gap = measured osm - calculated osm

  • Normal = +/- 14-10 mOsm/L

Differential Diagnosis

See Also

External Links

References