Oxacillin

General

• Type: Anti-Staphylococcal Penicillin
• Dosage Forms: IM; IV
• Common Trade Names:

Adult Dosing

General

• Mild-to-moderate infection
  • 250-500 mg IM/IV q4-6 hours
• Severe infection
  • 1g IM/IV q4-6 hours

Endocarditis

• 2g IV q4 hours + gentamicin

Prosthetic Joint Infection

• 2g IV q4 hours + rifampin

MSSA

• 2g IV q4 hours
• Examples: brain abscess, bursitis, erysipelas, mastitis, mastoiditis, osteomyelitis, perinephric abscess, pneumonia, pyomyositis, Scalded Skin Syndrome, Toxic Shock Syndrome

Pediatric Dosing

General

• Mild-to-moderate
  • 50 mg/kg/day IM/IV divided q6 hours
  • First Dose: 12.5 mg/kg IM/IV x 1
  • Max: 4 g/day
• Severe
  • 100 mg/kg/day IM/IV divided q4-6 hours
  • First Dose: 16.6-25 mg/kg IM/IV x 1
  • Max: 12 g/day

Community-Acquired Pneumonia (>3 Months)

• 150-200 mg/kg/day divided q6-8 hours
• First Dose: 37.5-66.6 mg/kg IV x 1
• For MSSA

Special Populations

• Pregnancy Rating: B
• Lactation: Use caution
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Fever
• Rash
• Nausea and Vomiting
• Diarrhea
• Eosinophilia
• Leukopenia
• Neutropenia
• Thrombocytopenia
• Agranulocytosis
• Hepatotoxicity
• AST increased
• Acute interstitial nephritis
• Hematuria
• Serum sickness-like reactions

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Antibiotics