Oxycodone: Difference between revisions
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==General== | ==General== | ||
*Type: opioid | *Type: [[opioid]] | ||
*Dosage Forms: PO | *Dosage Forms: PO | ||
*Common Trade Names: Roxicodone, Oxycontin | *Common Trade Names: Roxicodone, Oxycontin | ||
*Commonly combined with [[acetaminophen]] as Percocet | |||
==Adult Dosing== | ==Adult Dosing== | ||
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===Opioid-Experienced Patients=== | ===Opioid-Experienced Patients=== | ||
*Individualize based on current opioid intake q4-6h PRN | *Individualize based on current opioid intake q4-6h PRN | ||
*Taper dose by 25-50% q2-4 days to | **Use caution in older patients | ||
**See [[Opioids#Oral_Opioid_Dosing_Chart|Opioid Dosing Chart]] for dose conversion information | |||
**Taper dose by 25-50% q2-4 days to discontinue if long-term use | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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*Respiratory Depression | *Respiratory Depression | ||
*Apnea | *Apnea | ||
* | *[[Syncope]] | ||
* | *[[Bradycardia]] | ||
*Seizures | *[[Seizures]] | ||
* | *[[Anaphylaxis]] | ||
===Common=== | ===Common=== | ||
Revision as of 01:46, 21 February 2021
General
- Type: opioid
- Dosage Forms: PO
- Common Trade Names: Roxicodone, Oxycontin
- Commonly combined with acetaminophen as Percocet
Adult Dosing
Opioid-Naive Patients
- Start: 5-15mg PO q4-6h PRN
- Use lowest effective dose and shortest effective duration (NOT a first-line treatment)
- Use caution in older patients
Opioid-Experienced Patients
- Individualize based on current opioid intake q4-6h PRN
- Use caution in older patients
- See Opioid Dosing Chart for dose conversion information
- Taper dose by 25-50% q2-4 days to discontinue if long-term use
Pediatric Dosing
General Pain
- 0.05-0.15mg/kg PO q4-6h PRN
- Max: 5mg/dose
Special Populations
- Pregnancy Rating: C
- Lactation Risk Categories: possibly unsafe
- Renal Dosing
- Adult: CrCl < 60: decrease starting dose
- Pediatric: CrCl 10-50: decrease starting dose 25%, CrCL < 10: decrease dose 50%
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Respiratory Depression
- Apnea
- Syncope
- Bradycardia
- Seizures
- Anaphylaxis
Common
- Nausea
- Rash
- Headache
- Fatigue
- xerostomia
- constipation
- Tremor
- transaminitis
Pharmacology
- Half-life: 3.5-4 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action:binds to various opioid receptors