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General
- Type: Opioid
- Dosage Forms: PO
- Common Trade Names: Roxicodone, Oxycontin
- Commonly combined with acetaminophen as Percocet
Adult Dosing
Opioid-Naive Patients
- Start: 5-15mg PO q4-6h PRN
- Use lowest effective dose and shortest effective duration (NOT a first-line treatment)
- Use caution in older patients
Opioid-Experienced Patients
- Individualize based on current opioid intake q4-6h PRN
- Use caution in older patients
- See Opioid Dosing Chart for dose conversion information
- Taper dose by 25-50% q2-4 days to discontinue if long-term use
Pediatric Dosing
General Pain
- 0.05-0.15mg/kg PO q4-6h PRN
- Max: 5mg/dose
Special Populations
- Pregnancy Rating: C
- Lactation Risk Categories: possibly unsafe
- Renal Dosing
- Adult: CrCl < 60: decrease starting dose
- Pediatric: CrCl 10-50: decrease starting dose 25%, CrCL < 10: decrease dose 50%
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
Adverse Reactions
Serious
Common
- Nausea
- Rash
- Headache
- Fatigue
- xerostomia
- constipation
- Tremor
- transaminitis
Pharmacology
- Half-life: 3.5-4 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action:binds to various opioid receptors
