Difference between revisions of "Paromomycin"

(Paromomycin page)
 
Line 6: Line 6:
  
 
==Adult Dosing==
 
==Adult Dosing==
*Intestinal amebiasis: 25-35 mg/kg/day PO divided tid x5-10 days
+
===Intestinal [[amebiasis]]===
 +
*25-35 mg/kg/day PO divided tid x5-10 days
 
**Give w/ food
 
**Give w/ food
  
*Hepatic encephalopathy, adjunct tx: 1000 mg PO qid x5-6 days
+
===[[Hepatic encephalopathy]]===
 +
*adjunct tx: 1000 mg PO qid x5-6 days
 
**Give w/ food
 
**Give w/ food
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
*Intestinal amebiasis: 25-35 mg/kg/day PO divided tid x5-10 days
+
===Intestinal [[amebiasis]]===
 +
*25-35 mg/kg/day PO divided tid x5-10 days
  
 
==Special Populations==
 
==Special Populations==
Line 43: Line 46:
 
*enterocolitis
 
*enterocolitis
 
===Common===
 
===Common===
*nausea
+
*[[nausea]]
 
*abdominal cramps
 
*abdominal cramps
*diarrhea
+
*[[diarrhea]]
  
 
==Pharmacology==
 
==Pharmacology==
Line 61: Line 64:
 
==References==
 
==References==
 
<references/>
 
<references/>
[[UpToDate, Epocrates]]
+
UpToDate, Epocrates
 +
 
 +
[[Category:Drugs]]

Revision as of 12:17, 7 February 2016

Administration

  • Type: Amebicide
  • Dosage Forms: 250
  • Routes of Administration: Oral
  • Common Trade Names: Humatin

Adult Dosing

Intestinal amebiasis

  • 25-35 mg/kg/day PO divided tid x5-10 days
    • Give w/ food

Hepatic encephalopathy

  • adjunct tx: 1000 mg PO qid x5-6 days
    • Give w/ food

Pediatric Dosing

Intestinal amebiasis

  • 25-35 mg/kg/day PO divided tid x5-10 days

Special Populations

  • Poorly absorbed when given orally
  • Use during pregnancy has limited data

Renal Dosing

  • No change in dosing

Hepatic Dosing

  • No change in dosing

Contraindications

  • Allergy to class/drug
  • GI obstruction
  • caution if ulcerative colitis
  • caution if inflammatory bowel dz
  • caution if renal impairment

Adverse Reactions

Serious

  • nephrotoxicity
  • ototoxicity, auditory
  • ototoxicity, vestibular
  • neurotoxicity
  • neuromuscular blockade
  • malabsorption syndrome (prolonged use)
  • superinfection (prolonged use)
  • enterocolitis

Common

Pharmacology

  • Half-life: Unknown
  • Metabolism: CYP450
  • Excretion: Feces

Mechanism of Action

Bactericidal and amebicidal. Paromomycin binds to bacterial 30S ribosomal subunit, inhibiting protein synthesis; it suppresses urease producing bacteria, reducing ammonia absorption from gut

Comments

See Also

References

UpToDate, Epocrates